Relevance of vertical growth pattern in thin level II cutaneous superficial spreading melanomas

The American Journal of Surgical Pathology
M LefevreC Bailly

Abstract

Thin (<or=0.76 mm) level II cutaneous superficial spreading melanomas (SSMs) are known to be of excellent prognosis and very few recur, metastasize, or are lethal. Although many prognostic features at this stage have been studied, none appears to be statistically significant. The concept of tumor growth phase is correlated with Clark's level except for level II. SSM level II show either an invasive vertical growth phase or an invasive radial growth phase. The aim of our study (retrospective, multicenter, and case-control type) was to investigate the prognostic impact of vertical growth phase in thin level II cutaneous SSM. We identified 12 patients of poor outcome with complete initial excision. Each case was matched with three controls for gender, age, location, tumor thickness, and follow-up period since diagnosis. Independent pathologists studied all cases and controls. Univariate analyses were performed with a conditional logistic regression method. A kappa test was used to assess reproducibility between pathologists. Our study is the first and largest that shows that vertical growth phase is the only statistically significant prognostic factor for thin level II cutaneous SSM. We propose that growth phase evaluation (a mini...Continue Reading

References

Mar 1, 1978·Plastic and Reconstructive Surgery·A Breslow, S D Macht
Oct 1, 1991·British Journal of Cancer·W H Clark
May 1, 1990·The Journal of Dermatologic Surgery and Oncology·S M Salman, G S Rogers
Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
May 5, 1988·The New England Journal of Medicine·U VeronesiJ C Durand
Aug 1, 1988·Annals of Surgery·C L SlingluffH F Seigler
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J WalkerT K Das Gupta
Oct 1, 1987·Archives of Surgery·H M ShawG W Milton
Aug 1, 1986·Journal of the American Academy of Dermatology·G S RogersD F Roses
Feb 1, 1986·Cancer·P L NarunsD L Morton
Oct 1, 1985·Archives of Surgery·H M ShawG W Milton
Aug 1, 1983·European Journal of Cancer & Clinical Oncology·D T Zava, A Goldhirsch
Sep 1, 1984·International Journal of Dermatology·F H Rampen
Sep 15, 1980·Cancer·K S McCartyH F Seigler
Jan 1, 1983·Archives of Surgery·R R Paladugu, R H Yonemoto
Aug 1, 1983·Archives of Dermatology·G S RogersM M Mintzis
Aug 1, 1980·The British Journal of Surgery·G W MiltonW H McCarthy
May 1, 1994·Cancer·E Månsson-BrahmeL E Rutqvist
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D E ElderD Guerry
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G E Piérard, C Piérard-Franchimont
Dec 10, 1999·The American Journal of Surgical Pathology·H BreuningerG Rassner
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson

❮ Previous
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Citations

Dec 20, 2008·Clinics in Dermatology·Michael J PayetteJane M Grant-Kels
Jun 29, 2007·The British Journal of Dermatology·A PhanL Thomas
Jan 10, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Marie Louise Bønnelykke-BehrndtzTine Engberg Damsgaard
Aug 11, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C Halpern, A A Marghoob
Aug 11, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phyllis A GimottyDavid Elder
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phyllis A GimottyDupont Guerry
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phyllis A GimottyDupont Guerry
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Jun 29, 2004·Journal of Surgical Oncology·Richard A ScolyerStanley W McCarthy
Jul 26, 2014·The American Journal of Dermatopathology·Allen G StricklerMark R Wick
Oct 14, 2017·Chonnam Medical Journal·Luca RoncatiAntonio Del Gaudio
Oct 26, 2016·Melanoma Research·Francesco PiscioliLuca Roncati
Oct 2, 2009·Archives of Pathology & Laboratory Medicine·David P FrishbergUNKNOWN Members of the Cancer Committee, College of American Pathologists
Jul 8, 2011·Archives of Pathology & Laboratory Medicine·Doina Ivan, Victor G Prieto

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