Relevant and significant supervised gene clusters for microarray cancer classification

IEEE Transactions on Nanobioscience
Pradipta Maji, Chandra Das

Abstract

An important application of microarray data in functional genomics is to classify samples according to their gene expression profiles such as to classify cancer versus normal samples or to classify different types or subtypes of cancer. One of the major tasks with gene expression data is to find co-regulated gene groups whose collective expression is strongly associated with sample categories. In this regard, a gene clustering algorithm is proposed to group genes from microarray data. It directly incorporates the information of sample categories in the grouping process for finding groups of co-regulated genes with strong association to the sample categories, yielding a supervised gene clustering algorithm. The average expression of the genes from each cluster acts as its representative. Some significant representatives are taken to form the reduced feature set to build the classifiers for cancer classification. The mutual information is used to compute both gene-gene redundancy and gene-class relevance. The performance of the proposed method, along with a comparison with existing methods, is studied on six cancer microarray data sets using the predictive accuracy of naive Bayes classifier, K-nearest neighbor rule, and support v...Continue Reading

References

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P TamayoT R Golub
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·U AlonA J Levine
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WestJ R Nevins
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Feb 12, 2002·Bioinformatics·Danh V Nguyen, David M Rocke
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christophe Ambroise, Geoffrey J McLachlan
Jun 28, 2002·Cancer Cell·Dinesh SinghWilliam R Sellers
Jan 6, 2005·BMC Bioinformatics·Aditi Kanhere, Manju Bansal
Apr 27, 2005·Journal of Bioinformatics and Computational Biology·Chris Ding, Hanchuan Peng
Oct 19, 2006·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Wai-Ho AuYang Wang
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Pradipta Maji

❮ Previous
Next ❯

Citations

Oct 8, 2013·International Journal of Nanomedicine·Sushmita Paul, Pradipta Maji
Mar 7, 2014·IEEE Transactions on Nanobioscience·Jin-Xing LiuJane You
Jul 12, 2014·IEEE Transactions on Nanobioscience·Zhan-Li SunKin-Man Lam
Feb 6, 2021·Journal of Clinical Medicine·Shipra Agrawal On Behalf Of The Pediatric Nephrology Research Consortium Pnrc

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society
Pradipta Maji
Journal of Healthcare Engineering
Hussein Hijazi, Christina Chan
International Journal of Data Mining and Bioinformatics
Li-Juan ZhangHuo-Wang Chen
© 2021 Meta ULC. All rights reserved