Reliability and Accuracy of Peri-Interventional Stenosis Grading in Peripheral Artery Disease Using Color-Coded Quantitative Fluoroscopy: A Phantom Study Comparing a Clinical and Scientific Postprocessing Software

BioMed Research International
Patrick GhibesUlrich Grosse

Abstract

To assess quantitative stenosis grading by color-coded fluoroscopy using an in vitro pulsatile flow phantom. Three different stenotic tubes (80%, 60%, and 40% diameter restriction) and a nonstenotic reference tube were compared regarding their different flow behavior by using contrast-enhanced fluoroscopy with a flat-detector system for visualisation purposes. Time-density curves (TDC), area under the curve (AUC), time-to-peak (TTP), and different ROI sizes were analyzed in three independent measurements using two different postprocessing software solutions. In addition, exemplary TDCs of a patient with a high-grade stenosis before and after stent angioplasty were acquired. Color-coded fluoroscopy enabled depiction of differences in AUC and TDC between high-grade (80%), middle (60%), low-grade (40%), and nonstenotic tubes. The best correlation between high-, middle-, and low-grade stenosis was appreciated in ROIs behind the stenosis. This effect was enhanced by using longer integration times (5s, 7s) and a maximum frame rate of image acquisition for analysis (correlation coefficient rho=0.9284 at 5s). TTP showed no significant differences between high- and low-grade stenosis. Various clinical studies in the literature already d...Continue Reading

References

Nov 1, 1977·Annals of Surgery·D P FlaniganJ C Stanley
Jan 1, 1990·Journal of Biomechanics·B B Lieber, D P Giddens
Jul 1, 1974·Annals of Surgery·R Berguer, N H Hwang
Sep 21, 2001·Journal of Biomechanical Engineering·R MittalH S Udaykumar
Nov 21, 2007·The Journal of Thoracic and Cardiovascular Surgery·Michael MarklFriedhelm Beyersdorf
May 17, 2008·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·T FinkenzellerE M Jung
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar
Feb 20, 2010·AJNR. American Journal of Neuroradiology·C M StrotherM L Lindstrom
Mar 16, 2011·Annals of Biomedical Engineering·Ethan O KungCharles A Taylor
Jun 14, 2013·BioMed Research International·Sheng-Che HungCheng-Yen Chang
Apr 12, 2014·Cardiovascular and Interventional Radiology·Konstantinos KatsanosFabrizio Fanelli
Dec 17, 2014·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Caleb E FelicianoRafael Rodriguez-Mercado
Oct 9, 2015·Computational and Mathematical Methods in Medicine·Mehdi JahangiriMahmood Reza Sadeghi
Aug 3, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Rodrigo RiveraCatalina Merino-Osorio
Nov 10, 2017·Interventional Neurology·Christopher DonaldsonRonil V Chandra

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Citations

Jul 8, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Grace M Y MaPrakash Muthusami

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Methods Mentioned

BETA
X-
ray
X-ray
percutaneous angioplasty

Software Mentioned

ImageJ
iFlow
QTI Plot
QTI Plot Plot
JMP

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