Reliability and sensitivity of frozen-section pancreatic biopsy

Archives of Surgery
R P CampanaleG Higgins


A collaborative Veterans Administration and University of California, Davis Medical Center group of 586 patients with histologically proved pancreatic carcinoma was reviewed. During laparotomy, 159 patients underwent 251 frozen-section pancreatic biopsies with subsequent permanent section examination of the same tissue block. All 112 positive frozen-section diagnoses were corroborated on permanent sectioning. The 47 patients with false-negative biopsy specimens were equally divided between sampling and interpretation error. We conclude that in this group of 159 pancreatic cancer patients, 30% failed to be correctly diagnosed by intraoperative frozen-section biopsy. This failure was due to patient sampling and interpretation error in equal proportion. Interpretation error rates were not influenced by the type or number of biopsies. Patient sampling error is apparently reduced by repeated biopsy, and specimen sampling error occurred less frequently with wedge biopsy.


Feb 1, 1995·Annals of Surgery·K D Lillemoe
Feb 22, 2012·Journal of Visceral Surgery·D ChatelainJ-M Regimbeau
Feb 8, 2008·Surgical Oncology·James E Barone
Jan 1, 1996·American Journal of Surgery·S A BarensJ L Cameron
Mar 15, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·H DoucasD P Berry
Mar 28, 2007·International Journal of Surgery·Nazir A WaniMehmood A Wani
Jan 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·E A Stone
Oct 5, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Niccolo' PetruccianiGiovanni Ramacciato
Sep 18, 2015·International Journal of Surgical Pathology·Yong-Jun LiuDipti M Karamchandani
Jul 27, 1999·Veterinary Pathology·D L FritzD M Waag
Oct 1, 1989·Journal of Surgical Oncology·M WitzA Dinbar
Feb 21, 2002·Pancreas·Harald SchrammHans Bosseckert
Mar 28, 2008·ANZ Journal of Surgery·Reyad Al-GhnaniemAmeet G Patel

Related Concepts

False Negative Reactions
Frozen Sections
Intraoperative Period
Malignant Neoplasm of Pancreas

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