Reliability, Discriminative, and Prognostic Validity of the Multidimensional Symptom Index in Musculoskeletal Trauma.

The Clinical Journal of Pain
David M. Walton, Jacquelyn Marsh

Abstract

The Multidimensional Symptom Index (MSI) is a 10-item parallel score frequency×interference patient-reported outcome for use in clinical pain research. This manuscript describes results related to measurement stability, discriminative accuracy when screening for major depressive disorder (MDD), and prognostic validity when predicting recovery trajectories after acute musculoskeletal (MSK) trauma. Data were drawn from a longitudinal cohort study of adults with acute MSK trauma, supplemented by a secondary sample of adults with chronic pain. In a sample of n=23 stable participants over a 1-month period, reliability metrics indicated good stability for all 5 subscales (ICC3,1: 0.70 to 0.91). In a mixed acute/chronic sample (n=148), the Number of Symptoms and Nonsomatic Symptoms subscales showed clinically useful discriminative accuracy for MDD screening (area under the curve=0.86 and 0.88, respectively). In n=129 with acute MSK trauma, the Mean Interference and Nonsomatic Symptoms subscales showed significant prognostic validity for classifying participants into "recovery expected" or "recovery not expected" groups with 72.5% and 92.2% accuracy, respectively. The MSI holds promise as a tool for evaluating change, screening for MDD...Continue Reading

References

Dec 1, 1989·Controlled Clinical Trials·R JaeschkeG H Guyatt
Aug 1, 1987·Pain·Ronald Melzack
Feb 17, 1998·Statistics in Medicine·S D WalterA Donner
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Apr 24, 2007·The Spine Journal : Official Journal of the North American Spine Society·Anne G CopayThomas C Schuler
Aug 11, 2007·The Journal of Pain : Official Journal of the American Pain Society·Leighann Litcher-KellyArthur A Stone
Jun 13, 2009·The Journal of Orthopaedic and Sports Physical Therapy·Joy C MacDermidCharlie H Goldsmith
Apr 12, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Madeleine T King
Jan 17, 2013·The Journal of Orthopaedic and Sports Physical Therapy·David M WaltonCaroline A Zammit
Oct 12, 2013·The Open Orthopaedics Journal·David M WaltonUNKNOWN ICON
Oct 12, 2013·The Open Orthopaedics Journal·Joy C MacdermidUNKNOWN ICON
Nov 15, 2013·The Spine Journal : Official Journal of the North American Spine Society·YunHee ChoiRobert J Gatchel
Jan 13, 2015·The Journal of Orthopaedic and Sports Physical Therapy·John Schmitt, J Haxby Abbott
Nov 25, 2018·The Journal of Pain : Official Journal of the American Pain Society·Karen B Schmaling, Zachary A Nounou

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