Reliability of 95% confidence interval revealed by expected quality-of-life scores: an example of nasopharyngeal carcinoma patients after radiotherapy using EORTC QLQ-C 30.

Health and Quality of Life Outcomes
Tsair-Wei ChienAgnes L F Chan

Abstract

Many researchers use observed questionnaire scores to evaluate score reliability and to make conclusions and inferences regarding quality-of-life outcomes. The amount of false alarms from medical diagnoses that would be avoided if observed scores were substituted with expected scores is interesting, and understanding these differences is important for the care of cancer patients. Using expected scores to estimate the reliability of 95% confidence intervals (CIs) is rarely reported in published papers. We investigated the reliability of patient responses to a quality-of-life questionnaire and made recommendations for future studies of the quality of life of patients. A total of 115 patients completed the EORTC core questionnaire QLQ-C30 (version 3) after radiotherapy. The observed response scores, assumed to be one-dimensional, were summed and transformed into expected scores using the Rasch rating scale model with WINSTEPS software. A series of simulations was performed using a unified bootstrap procedure after manipulating scenarios with different questionnaire lengths and patient numbers to estimate the reliability at 95% confidence intervals. Skewness analyses of the 95% CIs were compared to detect different effects between ...Continue Reading

References

Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K BjordalS Kaasa
May 12, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Wen-Chung WangChing-Lin Hsieh
Jan 30, 2009·Medical Care Research and Review : MCRR·Jeffrey A Alexander, Larry R Hearld
Jun 19, 2009·BMC Medical Research Methodology·Tsair-Wei ChienShih-Bin Su
Aug 4, 2009·BMC Health Services Research·Tsair-Wei ChienHung-Jung Lin
May 4, 2010·Health and Quality of Life Outcomes·Adam B SmithValerie Jenkins

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Citations

Jul 23, 2013·Health and Quality of Life Outcomes·Zhen GuoWei Jiang
Aug 17, 2011·Journal of Medical Internet Research·Tsair-Wei ChienJulie Chi Chow
Jun 27, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C CanovaR Zanotti
Jan 17, 2013·European Journal of Cancer Care·M-Y TuM-Y Liu

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Software Mentioned

WINSTEPS
bootstrap
VBA
CTT
- VBA
SPSS
Excel

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