Reliability of clonidine testing for the diagnosis of growth hormone deficiency in children and adolescents

Clinical Endocrinology
Anastasia IbbaSandro Loche

Abstract

The diagnosis of growth hormone deficiency (GHD) is currently based on clinical, auxological, biochemical and neuro-radiological investigation. Provocative tests of GH secretion using physiological/pharmacological stimuli are required to confirm GHD. The clonidine test (CT) is widely used to assess GH secretory status. In this retrospective study, we analyzed the reliability of CT and the effect of puberty in a large number of children with short stature who had been evaluated for suspected GHD. Data were collected retrospectively from 327 children and adolescents with short stature (204 boys and 123 girls, median age 10.5 years (IQR 7.90-12.40) followed in four Italian Paediatric Endocrine Units (Cagliari, Genova, Napoli and Roma) between 2005 and 2013. All children underwent CT as the first GH stimulation test after exclusion of other known cause of their short stature. In 73 prepubertal children and 25 pubertal children, the GH peak after CT was <7 μg/L. GHD was confirmed in 87 (37 organic, 50 idiopathic). Six prepubertal and five pubertal patients showed false positive responses. The median BMI-SDS in these children was similar to that of children with GH peak ≥7 μg/L, and none were obese. Overall, the prevalence of false-p...Continue Reading

References

Aug 11, 1979·Lancet·I Gil-AdZ Laron
Jun 1, 1979·Acta Endocrinologica·L G MartinF D Camitta
Mar 1, 1976·Archives of Disease in Childhood·J M Tanner, R H Whitehouse
Aug 11, 1991·The Journal of Clinical Endocrinology and Metabolism·S R RoseG B Cutler
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·N MaurasJ D Veldhuis
Jan 1, 1985·American Journal of Diseases of Children·R LanesF Lifshitz
Nov 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W FinkelsteinL Hellman
Aug 1, 1972·The Journal of Clinical Endocrinology and Metabolism·R G ThompsomR M Blizzard
Sep 1, 1970·The Journal of Pediatrics·S D FrasierF G Smith
Feb 1, 1969·The Journal of Pediatrics·A W RootW R Eberlein
Nov 1, 1967·The Journal of Pediatrics·S D Frasier
Oct 1, 1967·The Journal of Clinical Endocrinology and Metabolism·L A FrohmanM H MacGillivray
Nov 1, 1983·The Journal of Pediatrics·R I RosenfieldD Bock
May 1, 1983·Archives of Disease in Childhood·N C FraserN S Brown
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J D MillerH J Guyda
Sep 1, 1983·The Journal of Pediatrics·F DammaccoE Frezza
May 1, 1982·The Journal of Pediatrics·R Lanes, E Hurtado
Dec 1, 1993·Journal of Endocrinological Investigation·S LocheC Pintor
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R G Rosenfeld
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·M CappaE E Müller
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·A S MartínezJ J Heinrich
Jul 21, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Martin W ElmlingerMichael B Ranke
Jun 24, 2006·European Journal of Endocrinology·Peter J TrainerGilbert Wieringaon
Sep 8, 2006·Journal of Endocrinological Investigation·E CacciariA Cicognani
Jun 11, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Saravik MolinaRoberto Lanes
Sep 30, 2008·European Journal of Endocrinology·Martin Bidlingmaier
Dec 30, 2014·Indian Journal of Endocrinology and Metabolism·Ashraf SolimanVincenzo De Sanctis
Jul 15, 2015·Archives of Disease in Childhood·P G MurrayP E Clayton

❮ Previous
Next ❯

Citations

Dec 28, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Vipin GuptaGovind K Makharia
Oct 17, 2019·Frontiers in Endocrinology·João Soares FelícioJoão Felício Abrahão Neto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved