Reliability of CT perfusion-derived CBF in relation to hemodynamic compromise in patients with cerebrovascular steno-occlusive disease: a comparative study with 15O PET

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Masanobu IbarakiToshibumi Kinoshita

Abstract

In the bolus tracking technique with computed tomography (CT) or magnetic resonance imaging, cerebral blood flow (CBF) is computed from deconvolution analysis, but its accuracy is unclear. To evaluate the reliability of CT perfusion (CTP)-derived CBF, we examined 27 patients with symptomatic or asymptomatic unilateral cerebrovascular steno-occlusive disease. Results from three deconvolution algorithms, standard singular value decomposition (sSVD), delay-corrected SVD (dSVD), and block-circulant SVD (cSVD), were compared with (15)O positron emission tomography (PET) as a reference standard. To investigate CBF errors associated with the deconvolution analysis, differences in lesion-to-normal CBF ratios between PET and CTP were correlated with prolongation of arterial-tissue delay (ATD) and mean transit time (MTT) in the lesion hemisphere. Computed tomography perfusion results strongly depended on the deconvolution algorithms used. Standard singular value decomposition showed ATD-dependent underestimation of CBF ratio, whereas cSVD showed overestimation of the CBF ratio when MTT was severely prolonged in the lesions. The computer simulations reproduced the trend observed in patients. Deconvolution by dSVD can provide lesion-to-nor...Continue Reading

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Citations

Nov 21, 2017·Nihon Hoshasen Gijutsu Gakkai zasshi·Tomomi Ohmura
Jun 6, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanobu IbarakiToshibumi Kinoshita
Feb 26, 2016·World Journal of Nuclear Medicine·Masashi KameyamaMasahiro Jinzaki

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Software Mentioned

cSVD
SVD
dSVD
R
SPM8

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