Reliability of Early Magnetic Resonance Imaging (MRI) and Necessity of Repeating MRI in Noncooled and Cooled Infants With Neonatal Encephalopathy

Journal of Child Neurology
Elavazhagan ChakkarapaniV Chau

Abstract

In cooled newborns with encephalopathy, although late magnetic resonance imaging (MRI) scan (10-14 days of age) is reliable in predicting long-term outcome, it is unknown whether early scan (3-6 days of life) is. We compared the predominant pattern and extent of lesion between early and late MRI in 89 term neonates with neonatal encephalopathy. Forty-three neonates (48%) were cooled. The predominant pattern of lesions and the extent of lesion in the watershed region agreed near perfectly in noncooled (kappa = 0.94; k = 0.88) and cooled (k = 0.89; k = 0.87) infants respectively. There was perfect agreement in the extent of lesion in the basal nuclei in noncooled infants (k = 0.83) and excellent agreement in cooled infants (k = 0.67). Changes in extent of lesions on late MRI occurred in 19 of 89 infants, with higher risk in infants with hypoglycemia and moderate-severe lesions in basal nuclei. In most term neonates with neonatal encephalopathy, early MRI (relative to late scan) robustly predicts the predominant pattern and extent of injury.

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Citations

Jan 16, 2019·Journal of Child Neurology·Qi XuElke H Roland
Feb 6, 2019·Nanomaterials·Stefania NardecchiaHouria Boulaiz
Apr 25, 2019·Journal of Intellectual Disability Research : JIDR·A J Fernández-SolanoM Rodríguez-Bailón
Jul 12, 2019·Archives of Disease in Childhood. Education and Practice Edition·Paul Cawley, Ela Chakkarapani
Jan 18, 2019·Paediatrics & Child Health·Brigitte Lemyre, Vann Chau
Sep 19, 2018·Seizure : the Journal of the British Epilepsy Association·Mark P FitzgeraldNicholas S Abend

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