Reliability of frozen section examination of obturator lymph nodes and impact on lymph node dissection borders during radical cystectomy: results of a prospective multicentre study by the Turkish Society of Urooncology

BJU International
Sümer BaltaciYasar Beduk

Abstract

To evaluate the accuracy of frozen section examination (FSE) for detecting lymph node (LN) metastases and whether we can use this information to decide the extent of LN dissection during cystectomy. From August 2005 to August 2009 FSE of obturator LNs was performed in 118 patients with bladder cancer, who were undergoing radical cystectomy with extended LN dissection. Removed tissues from 12 well defined LN regions were sent separately for pathologic evaluation. The FSE results of obturator regions were compared with the final histopathologic results of these node regions. The mean number of removed nodes per patient was 29.4 ± 9.3 (median 28, range 12 to 51). The sensitivity, specificity, positive and negative predictive values of FSE for the 118 right obturator LN regions were 94.7%, 100%, 100% and 99%, respectively. The same values for the 118 left obturator LN regions were 86.7%, 100%, 100% and 98.1%, respectively. At final pathologic examination 28 of 118 (23.7%) patients had LN metastasis at obturator regions. Skipped metastasis was found in 15/90 patients (16.7%). Clinical and pathological stage of the primary tumour were found to be significant parameters for skipped metastasis (P = 0.008 and P < 0.001, respectively). P...Continue Reading

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Citations

Apr 29, 2011·International Journal of Clinical Oncology·Hiroshi KitamuraTaiji Tsukamoto
May 25, 2011·International Journal of Clinical Oncology·Hiroshi KitamuraTaiji Tsukamoto
Aug 21, 2012·The Journal of Urology·Todd M MorganMichael S Cookson
Jun 5, 2012·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·S LarréC Pfister
Mar 9, 2012·Der Urologe. Ausg. A·T MetzgerP Zehnder
Dec 18, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·N CerfT Lebret

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