Reliability of Intra-Retinal Layer Thickness Estimates

PloS One
Timm OberwahrenbrockAlexander U Brandt

Abstract

Measurement of intra-retinal layer thickness using optical coherence tomography (OCT) has become increasingly prominent in multiple sclerosis (MS) research. Nevertheless, the approaches used for determining the mean layer thicknesses vary greatly. Insufficient data exist on the reliability of different thickness estimates, which is crucial for their application in clinical studies. This study addresses this lack by evaluating the repeatability of different thickness estimates. Studies that used intra-retinal layer segmentation of macular OCT scans in patients with MS were retrieved from PubMed. To investigate the repeatability of previously applied layer estimation approaches, we generated datasets of repeating measurements of 15 healthy subjects and 13 multiple sclerosis patients using two OCT devices (Cirrus HD-OCT and Spectralis SD-OCT). We calculated each thickness estimate in each repeated session and analyzed repeatability using intra-class correlation coefficients and coefficients of repeatability. We identified 27 articles, eleven of them used the Spectralis SD-OCT, nine Cirrus HD-OCT, two studies used both devices and two studies applied RTVue-100. Topcon OCT-1000, Stratus OCT and a research device were used in one stu...Continue Reading

References

Nov 22, 1991·Science·D HuangC A Puliafito
Apr 3, 2001·Nature Medicine·W DrexlerJ G Fujimoto
Dec 13, 2007·Optics Letters·W DrexlerJ G Fujimoto
Apr 26, 2008·Investigative Ophthalmology & Visual Science·Stacey S ChoiJohn S Werner
Jun 3, 2009·Nature Reviews. Neurology·Frederik BarkhofStephen C Reingold
Jan 22, 2011·Brain : a Journal of Neurology·Shiv SaidhaPeter A Calabresi
May 21, 2011·Brain : a Journal of Neurology·A U BrandtS Schippling
Jun 10, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Emma C DaviesLaura J Balcer
Oct 19, 2011·Brain : a Journal of Neurology·Stephanie B SycPeter A Calabresi
Jan 10, 2012·Investigative Ophthalmology & Visual Science·Prema SriramAlexander Klistorner
Mar 1, 2012·Ophthalmology·Scott D WalterLaura J Balcer
Mar 6, 2012·Multiple Sclerosis : Clinical and Laboratory Research·P AlbrechtA Methner
Apr 27, 2012·PloS One·Prejaas TewarieAxel Petzold
Aug 14, 2012·Multiple Sclerosis International·Timm OberwahrenbrockAlexander U Brandt
Sep 1, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Hanna ZimmermannAlexander U Brandt
Mar 22, 2013·Neurology·Elias S SotirchosPeter A Calabresi
May 11, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yanling OuyangSrinivas R Sadda
May 25, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Timm OberwahrenbrockFriedemann Paul
May 30, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Iñigo GabilondoPablo Villoslada
Jun 19, 2013·Journal of Neurology·Lauren A SeyerDavid R Lynch
Jan 10, 2014·Multiple Sclerosis : Clinical and Laboratory Research·L J BalkA Petzold
Mar 19, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Divya NarayananLaura J Frishman
May 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Nicolas M RothFriedemann Paul
May 27, 2014·Neurology·Alexander U BrandtFriedemann Paul
Jun 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·S SchipplingA Petzold
Jul 23, 2015·Retina·Alexander U BrandtJan Dörr

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Citations

Sep 2, 2016·Brain : a Journal of Neurology·Benjamin KnierThomas Korn
Apr 27, 2016·IEEE Transactions on Medical Imaging·Jun ChengJiang Liu
Nov 11, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Anna M PietroboniDaniela Galimberti
Jun 4, 2018·Investigative Ophthalmology & Visual Science·Atsuro UchidaJustis P Ehlers
Jan 6, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Nikolaus FeuchtBenjamin Knier
Jun 23, 2018·Brain and Behavior·Gro Helen DaleToke Bek
Jun 21, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Frederike C OertelAlexander U Brandt
Dec 28, 2018·Expert Review of Neurotherapeutics·Frederike C OertelFriedemann Paul
Mar 10, 2019·Annals of Neurology·Rachel C Nolan-KenneyUNKNOWN International Multiple Sclerosis Visual System Consortium
Aug 1, 2019·Brain : a Journal of Neurology·Willemien A de Vries-KnoppertAxel Petzold
Mar 4, 2017·Neurology. Neuroimmunology and Neuroinflammation·Frederike C OertelAlexander U Brandt
Jan 24, 2020·Neurology. Neuroimmunology and Neuroinflammation·Carla A WickiSven Schippling
Mar 20, 2018·Neurology. Neuroimmunology and Neuroinflammation·Timm OberwahrenbrockSven Schippling
Apr 6, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kevin K TongMeng C Lin
Nov 13, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Laura J BalcerShiv Saidha
Apr 2, 2020·Neurology. Neuroimmunology and Neuroinflammation·Hanna G Zimmermann, Frederike Cosima Oertel
Apr 26, 2019·Frontiers in Neuroscience·Benjamin J KimDavid J Irwin
Oct 3, 2017·Biomedical Optics Express·Sunil Kumar YadavAlexander U Brandt
Apr 23, 2016·Journal of Biomedical Materials Research. Part a·Aylin KomezVasif Hasirci
May 16, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Jeffrey LambeRobert A Bermel
Jul 7, 2020·Movement Disorders Clinical Practice·Frederike Cosima OertelAlexander U Brandt
Oct 13, 2020·Frontiers in Neurology·Lucia ZiccardiVincenzo Parisi
Nov 28, 2017·Journal of Affective Disorders·Carlos Schönfeldt-LecuonaMaximilian Gahr
May 20, 2021·Annals of Clinical and Translational Neurology·Axel PetzoldUNKNOWN IMSVISUAL, ERN-EYE Consortium
Sep 17, 2021·Neurology. Neuroimmunology and Neuroinflammation·Frederike Cosima OertelFriedemann Paul

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Software Mentioned

Heidelberg Eye Explorer
Eye Explorer
ICC
R
Cirrus
Matlab

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