PMID: 3769373Nov 1, 1986Paper

Reliability of plasma creatinine measurement in infants and children

Clinical Pediatrics
M J ClermontG J Schwartz

Abstract

Plasma creatinine (Pcr, mg/dl) is often used to estimate glomerular filtration rate (GFR) in children. To establish whether the clinician can rely on the commonly used methods for measuring Pcr, the authors analyzed data from their own modified Technicon Autoanalyzer reference method and compared them to those obtained simultaneously from a Beckman Astra 8 kinetic Jaffe technique or a Technicon continuous flow Jaffe endpoint SMAC method. The SMAC method consistently overestimated Pcr by 0.1 mg/dl, whereas the kinetic method resulted in a large spread around the reference values. Neither laboratory gave consistent results for Pcr below 0.55, the normal range for infants and young children. The SMAC technique tended to underestimate GFR by 20 to 30 percent, whereas the kinetic method resulted in a great deal of scatter (only 37% of the measurements fell within +/- 25% of the values for GFR obtained by the reference method). The results suggest that the subtraction of 0.1 mg/dl from the Pcr measured on the SMAC system would give a value similar to that obtained with the reference method. This correction would permit the use of an estimate of GFR from kL/Pcr, where L is body length in cm and k is a constant (equalling 0.45 in term ...Continue Reading

References

May 1, 1976·The Journal of Pediatrics·G J SchwartzA Spitzer
Feb 1, 1985·The Journal of Pediatrics
Mar 1, 1985·The Journal of Pediatrics·G J Schwartz, B Gauthier
Mar 1, 1983·Archives of Disease in Childhood·J P Guignard

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Citations

Nov 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L P BrionG J Schwartz
Oct 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A W WilliamsD S Milliner
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L P BrionG J Schwartz
Nov 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G J Schwartz
Mar 27, 1999·The Pediatric Infectious Disease Journal·O O FofahL P Brion
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Feb 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George J Schwartz
Dec 17, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert L Chevalier
Jun 20, 2015·Advances in Chronic Kidney Disease·Robert L Chevalier
May 1, 1987·Archives of Environmental Health·J Schwartz, D Otto
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George J Schwartz, Dana F Work
Jan 1, 1996·Annual Review of Psychology·R Karniol, M Ross
Mar 1, 1997·Journal of Advanced Nursing·L Alsop-Shields, H Alexander
Sep 17, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kiarad FendereskiAbdol-Mohammad Kajbafzadeh
May 1, 1990·Archives of Disease in Childhood·K P FungD P Davis
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Jolanta M DzikElzbieta Walajtys-Rode
Mar 5, 2020·Journal of the American Society of Nephrology : JASN·Behzad NajafianMichael Mauer

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