Sep 1, 1977

Reliability of salivary theophylline as a guide to plasma theophylline levels

American Journal of Diseases of Children
S P GalantJ J Orcutt


Simultaneous saliva and plasma theophylline levels in 12 chronic asthmatic children were measured by high pressure liquid chromatography following administration of a theophylline preparation. In five subjects, simultaneous plasma and salivary theophylline were measured one week later. A strongly positive correlation between plasma and salivary theophylline levels was found at all time periods tested. There was no substantial difference in the plasma-saliva theophylline ratio determined one week later. A predicted plasma level was compared with the observed value. The proportionality of predicted to observed plasma theophylline levels using either the entire study group mean plasma-saliva ratio or each individual's ratio was approximately 1.00 with 9% variability. When a previously reported plasma-saliva theophylline ratio was used for comparison, the predicted plasma theophylline was 15% above the observed plasma level.

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Mentioned in this Paper

Saliva - SpecimenType
High Pressure Liquid Chromatography Procedure
Theophylline Assay
Liquid Chromatography

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