Reliability of serum biomarkers of inflammation from repeated measures in healthy individuals.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Sandi L NavarroJohanna W Lampe

Abstract

Biomarkers of low-grade systemic inflammation are used to study the associations of inflammation with chronic diseases, including cancer. However, relatively little is known about the intraindividual variability of most of these measures. Fasting serum samples, collected at baseline and the end of ≥3-week washout periods in a four-diet crossover feeding trial, were used to measure the inflammatory markers high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-8, and soluble TNF receptor (sTNFR) I and II. Participants included 62 men and women for analyses of IL-6 and CRP and 56 for analyses of IL-8, TNF-α, and sTNFRs, aged 20 to 40, who were free of factors known to influence inflammation, for example, chronic disease, medication use, heavy alcohol use, smoking, and obesity (body mass index >30 kg/m(2)). Intraclass correlations (ICC) were estimated using random effects ANOVA, across all four time points (~6 weeks apart). ICCs for TNF-α and sTNFR I and II were very high: ICC = 0.92 [95% confidence interval (CI), 0.89-0.96], 0.92 (95% CI, 0.88-0.95), and 0.90 (95% CI, 0.85-0.94), respectively. ICCs for IL-8 and hsCRP were 0.73 (95% CI, 0.63-0.83) and 0.62 (95% CI, 0.49-0.75), respective...Continue Reading

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May 20, 2014·Cancer Causes & Control : CCC·Sheetal HardikarEmily White
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