Reliability of symmetric dimethylarginine in dogs with myxomatous mitral valve disease as kidney biomarker

Open Veterinary Journal
A SavareseP G Brambilla

Abstract

The most common cause of heart failure in the canine population is myxomatous mitral valve disease, sometimes complicated by chronic kidney disease. Many studies have been done on the use of symmetric dimethylarginine as biomarker of renal impairment in dogs affected by chronic kidney disease, few studies have examined his reliability as biomarker in dogs affected by heart diseases. Aim of this study was to evaluate symmetric dimethylarginine in dogs affected by mitral valve disease in order to assess his reliability in heart diseases. This was a retrospective case-control study on a clinical population of dogs affected by mitral valve disease (cases) vs healthy dogs (controls). Both groups underwent a complete physical evaluation, echocardiographic examination, complete blood count, biochemical panel, including serum creatinine and urea and urine analysis with protein-to-creatinine ratio. Serum was frozen and sent to IDEXX laboratories for symmetric dimethylarginine determination. General linear model was applied to data. A total number of 24 cases and 7 controls were included. Symmetric dimethylarginine value was in the reference value in the 75% (n=18) of cases, and in the 43% (n=3) of controls. Once set symmetric dimethylar...Continue Reading

Citations

Apr 1, 2019·Veterinary World·Yury A VatnikovAndrey N Zharov
Nov 14, 2020·The Journal of Small Animal Practice·H J SargentR E Jepson
Feb 11, 2021·The Journal of Veterinary Medical Science·Chayanont BhamarasutaChollada Buranakarl
Jun 11, 2021·Equine Veterinary Journal·Hsiao-Chien LoHeidrun Gehlen
Sep 8, 2021·Environmental Science and Pollution Research International·Youssef M Y ElgazzarMahmoud A Y Helal
Oct 5, 2021·Frontiers in Veterinary Science·Carlotta ValenteHelen Poser
Oct 13, 2021·Toxicologic Pathology·Rebecca KohnkenBruce LeRoy

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