Reliability of the bright liver echo pattern in diagnosing steatosis in patients with cryptogenic and HCV-related hypertransaminasaemia

Clinical Radiology
M SoresiG Montalto

Abstract

To evaluate the reliability of the bright liver (BL) echo pattern on ultrasound to detect histological steatosis in chronic cryptogenic hypertransaminasaemia (CCH) and hepatitis C virus (HCV)-related forms of hypertransaminasaemia. One hundred and fifty patients, 54 with CCH and 96 with HCV hypertransaminasaemia (76 genotype 1/2 and 20 genotype 3), were enrolled. Histological steatosis was measured as the percentage of hepatocytes involved. The reliability of the BL sign was estimated using the sensitivity, specificity, positive and negative predictive values. Histological steatosis was present in 102/150 patients (68%) divided into 59/96 (62%) in the HCV group and 43/54 (79.6%) in the CCH group (chi(2)=4.4; p=0.035). In a multivariate analysis, the variable associated with the BL echo pattern was steatosis percentage (p=0.0018). Steatosis percentage was higher in CCH group than in the HCV genotype 1/2 and 3 groups (p=0.02). The sensitivity of the BL echo pattern was 88% in the CCH group [confidence interval (CI) 95% 74-95] versus 61% (CI 95% 44-73) in the HCV genotype 1/2 group. The CI indicates that ultrasound can provide evidence for steatosis in a statistically significant way in the CCH versus HCV genotype 1/2 patients. In...Continue Reading

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Citations

Apr 14, 2015·Gastroenterology Research and Practice·S GittoP Andreone
Mar 29, 2011·Analytical Biochemistry·Etienne MalvoisinNadine Vincent
May 9, 2018·Expert Review of Anti-infective Therapy·Fabienne MarcellinMaria Patrizia Carrieri
Feb 9, 2018·Internal and Emergency Medicine·Anna LicataMaurizio Soresi
Jan 7, 2015·World Journal of Gastroenterology : WJG·Maurizio SoresiGiuseppe Montalto
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
Jun 24, 2017·BioMed Research International·Maurizio SoresiLydia Giannitrapani
Jul 16, 2014·Deutsches Ärzteblatt International·Johannes WeißAndreas Geier

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