Reliability of the detection of meningococcal gamma-glutamyl transpeptidase as an identification marker for Neisseria meningitidis

Microbiology and Immunology
Hideyuki TakahashiHaruo Watanabe


Detection of gamma-glutamyl transpeptidase (GGT; ggt ) activity is one of the useful methods for a specific identification of Neisseria meningitidis. However, we previously happened to isolate a ggt -deficient N. meningitidis strain (NIID113) from a healthy carrier. In this study, in order to re-examine the reliability of the marker, we again investigated the GGT activity of 245 N. meningitidis human isolates and identified two other GGT-defective N. meningitidis isolates besides NIID113. The isolation frequency (1.2%) of ggt mutants among human isolates strongly confirmed the 98.8% reliability of GGT activity as the identification marker for N. meningitidis.


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Feb 21, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hideyuki TakahashiMakoto Ohnishi
May 21, 2013·Tropical Medicine & International Health : TM & IH·MenAfriCar Consortium
Jul 25, 2009·Nihon saikingaku zasshi. Japanese journal of bacteriology·Hideyuki Takahashi

Related Concepts

Carrier of Disorder
Gamma-glutamyl transferase
Genes, Bacterial
Meningococcal Infections
Neisseria meningitidis
Reproducibility of Results

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