Reliability of transcriptional cycles and the yeast cell-cycle oscillator.

PLoS Computational Biology
Volkan SevimJoshua E S Socolar

Abstract

A recently published transcriptional oscillator associated with the yeast cell cycle provides clues and raises questions about the mechanisms underlying autonomous cyclic processes in cells. Unlike other biological and synthetic oscillatory networks in the literature, this one does not seem to rely on a constitutive signal or positive auto-regulation, but rather to operate through stable transmission of a pulse on a slow positive feedback loop that determines its period. We construct a continuous-time Boolean model of this network, which permits the modeling of noise through small fluctuations in the timing of events, and show that it can sustain stable oscillations. Analysis of simpler network models shows how a few building blocks can be arranged to provide stability against fluctuations. Our findings suggest that the transcriptional oscillator in yeast belongs to a new class of biological oscillators.

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Citations

Oct 5, 2012·Journal of the Royal Society, Interface·Xianrui ChengJoshua E S Socolar
Nov 13, 2012·Methods : a Companion to Methods in Enzymology·Assieh Saadatpour, Réka Albert
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Aug 6, 2014·Journal of Theoretical Biology·Mengyang SunJoshua E S Socolar
Sep 5, 2015·PLoS Computational Biology·Elizabeth Ortiz-GutiérrezElena R Álvarez-Buylla
Aug 31, 2012·BMC Systems Biology·Gautier StollLaurence Calzone
Nov 22, 2011·PLoS Computational Biology·Krešimir JosićMatthew R Bennett
Apr 8, 2015·PLoS Computational Biology·Jorge G T Zañudo, Réka Albert
Oct 21, 2016·ELife·Patrick HillenbrandUlrich Gerland
Jun 9, 2018·Quantitative Biology·Zhengda Li, Qiong Yang
Sep 13, 2018·Molecular Biology of the Cell·Christina M KelliherSteven B Haase
Jul 24, 2021·PLoS Computational Biology·Zhongneng Xu, Shuichi Asakawa

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