PMID: 11343952May 10, 2001Paper

Reliable long-term non-pulsatile circulatory support without anticoagulation

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
S SaitoC Nojiri

Abstract

The Terumo implantable left ventricular assist system (T-ILVAS) consists of a titanium centrifugal pump with a unique magnetically suspended impeller producing continuous (non-pulsatile) flow up to 10 l/min. The interior surface is heparin-coated and there is no purge system. We implanted the device into six sheep to ascertain in-vivo haemodynamic function, mechanical reliability and biocompatibility. The T-ILVAS was implanted via left thoracotomy without cardiopulmonary bypass. The inflow cannula was placed in the left ventricular apex and a Dacron outflow graft anastomosed to the descending aorta. All animals recovered well. No anticoagulation (heparin or warfarin) was given after the surgery. Suspension position, motor current, impeller speed and pump flow were continuously monitored and stored by on-line computer. Serial blood samples were collected to determine haematological and biochemical indices of renal function, liver function and haemolysis. All animals were electively euthanized between 3 and 7 months postoperatively. The explanted pumps were examined for mechanical reliability and thrombus formation. Major organs were examined macroscopically and histologically for thromboembolism. All animals appeared completely ...Continue Reading

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Citations

Feb 24, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michiel MorshuisChisato Nojiri
Mar 2, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus ThalmannErnst Wolner
Dec 15, 2005·Heart, Lung & Circulation·Patrick M McCarthyKatherine J Hoercher
Jun 20, 2002·Artificial Organs·Kiyotaka FukamachiLeonard A R Golding
Jan 22, 2003·Artificial Organs·Anita L van der MeerJohn C Woodard
May 10, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stephen Westaby, Mario Deng
Jul 5, 2012·Interactive Cardiovascular and Thoracic Surgery·Michele RossiAttilio Renzulli
Jul 29, 2005·Artificial Organs·Yoshinori Mitamura, Shun Murabayashi
May 11, 2006·Artificial Organs·Hideo HoshiSetsuo Takatani
Jul 2, 2009·Artificial Organs·Diyar Saeed, Kiyotaka Fukamachi
Nov 29, 2008·Seminars in Thoracic and Cardiovascular Surgery·Francis D Pagani
Apr 1, 2004·The Surgical Clinics of North America·Stephen Westaby
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Egemen TuzunBranislav Radovancevic
Jun 19, 2007·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takashi YamaneTatsuo Tsutsui
Jul 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Vance G NielsenTruitt C Ellis
Jun 14, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Setsuo TakataniTakashi Yamane
Jul 1, 2010·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Duc Q Nguyen, Vinod H Thourani
Oct 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Satoshi Saito, Tomohiro Nishinaka
Nov 19, 2013·Critical Care Medicine·Alexandra K PrattSteven W Boyce
Jun 13, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yoshie OchiaiKiyotaka Fukamachi
Mar 11, 2010·Expert Review of Medical Devices·Michiel MorshuisLatif Arusoglu
Jun 28, 2017·World Journal of Gastroenterology : WJG·Grigoriy E Gurvits, Elena Fradkov
Oct 6, 2006·Current Opinion in Anaesthesiology·Edith CollardLuc M Jacquet
Feb 9, 2002·Science·Patrick M McCarthy, William A Smith

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