Reliable routine method for determination of perazine in serum by thin-layer chromatography with an internal standard

Journal of Chromatography
M KresseB Müller-Oerlinghausen

Abstract

The use of a high-performance thin-layer chromatography linear chamber and of thioridazine as internal standard increases the performance of thin-layer chromatography (TLC) with direct densitometric scanning, and allows the rapid determination of serum levels of the neuroleptic drug perazine under usual therapeutic conditions. TLC is superior to gas-liquid chromatography in so far as the main metabolite desmethylperazine can be easily separated and detected by the same procedure.

Citations

Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·W GaebelJ Schley
Apr 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G Colman

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