Reliable timescale inference of HBV genotype A origin and phylodynamics

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Gianguglielmo ZehenderMassimo Ciccozzi

Abstract

The worldwide distributed Hepatitis B virus (HBV) genotype A is classified into three subgenotypes, and one quasi-subgenotype. The majority of HBV-A subgenotypes are widespread in Africa and in ethnic groups that have relatively recently emigrated from African countries, whereas HBV-A2 is highly prevalent among subjects at high risk for sexual exposure to HBV in north-western Europe and the USA. The aim of this study was to reconstruct the origin and dispersion of HBV-A subgenotypes on a reliable timescale using short-term calibration based on heterochronous sampling for HBV-A2, and long-term calibration based on historical data for the other subgenotypes. To this aim, we analysed 113 newly characterised HBV-A isolates with 247 reference sequences retrieved from a public database. The phylodynamic reconstruction was performed by a Bayesian framework. The common ancestor of the currently circulating A subgenotypes was placed in west-central Africa a mean 1057 years ago. The genotype diverged into two main clades at the beginning of the 13th century: one including all of the west-central African quasi-subgenotypes and the other corresponding to subgenotype A1, originating in east Africa and further segregating into two main subcl...Continue Reading

References

Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Strimmer, A von Haeseler
Mar 22, 2002·The Journal of General Virology·Anna KramvisMichael C Kew
Apr 6, 2002·Bioinformatics·Heiko A SchmidtArndt von Haeseler
Feb 11, 2005·Molecular Biology and Evolution·A J DrummondO G Pybus
Jul 19, 2006·Journal of Medical Virology·Arup BanerjeeRunu Chakravarty
Feb 7, 2007·Virus Research·Marisol Devesa, Flor H Pujol
Apr 25, 2007·Virology·Chiara De MaddalenaGianguglielmo Zehender
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Kramvis, Michael C Kew
Aug 9, 2007·Journal of Molecular Evolution·Yang Zhou, Edward C Holmes
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Jun 21, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Manoj V MurhekarSubhash C Sehgal
Aug 22, 2008·Virology·Gianguglielmo ZehenderMassimo Galli
Jan 10, 2009·Human Biology·Mansi GauniyalGautam K Kshatriya
May 29, 2009·Reviews in Medical Virology·Iris E AndernachClaude P Muller
Sep 16, 2009·Emerging Infectious Diseases·Iris E AndernachClaude P Muller
Oct 28, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mahmoud Reza PourkarimMarc Van Ranst
May 5, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Natalia M AraujoAlan Kay
Jul 12, 2011·Molecular Ecology·Simon Y W HoAlan Cooper
Nov 17, 2011·Antiviral Research·Valentina SvicherCarlo Federico Perno
Aug 22, 2012·The American Journal of Tropical Medicine and Hygiene·Márcia da Costa CastilhoWornei Silva Miranda Braga
Sep 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dimitrios ParaskevisAngelos Hatzakis
Jun 26, 2013·Antiviral Therapy·Anna Kramvis, Dimitrios Paraskevis
Sep 10, 2013·Seminars in Cancer Biology·Stephen LocarniniLilly Yuen
Jul 1, 2014·World Journal of Gastroenterology : WJG·Gianguglielmo ZehenderMassimo Galli
Jul 19, 2014·Intervirology·Anna Kramvis

❮ Previous
Next ❯

Citations

Feb 2, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gianguglielmo ZehenderElisabetta Tanzi
Jun 6, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tetyana I VasylyevaGkikas Magiorkinis
Jun 9, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bibiane A GodoyNelson J R Fagundes
Jun 28, 2019·Journal of Medical Virology·Massimo CiccozziSilvia Angeletti
Sep 22, 2019·Viruses·Barbara V LagoFrancisco C A Mello
May 11, 2018·Nature·Barbara MühlemannEske Willerslev
Apr 25, 2021·Journal of Viral Hepatitis·Jolynne MokayaPhilippa C Matthews
May 2, 2021·Journal of Viral Hepatitis·Jonas Michel WolfVagner Ricardo Lunge
May 24, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jonas Michel WolfVagner Ricardo Lunge
Jun 11, 2021·Frontiers in Microbiology·Stephen A LocarniniLilly K W Yuen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Related Papers

Journal of Medical Virology
Massimo CiccozziMarco Ciotti
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Gianguglielmo ZehenderMassimo Ciccozzi
World Journal of Gastroenterology : WJG
Gianguglielmo ZehenderMassimo Galli
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Gianguglielmo ZehenderLuisa Romanò
© 2021 Meta ULC. All rights reserved