Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF)

Neurocase
V S RamachandranAlbert Lin

Abstract

AL's leg was amputated resulting in phantom-limb pain (PLP). (1) When a volunteer placed her foot on or near the phantom - touching it evoked organized sensations in corresponding locations on AL's phantom. (2) Mirror-visual-feedback (MVF) relieved PLP, as did, "phantom massage". (3) Psilocybin-MVF pairing produced synergistic effects, complete elimination of PLP, and reduction in paroxysmal episodes. (4) Touching the volunteer's leg where AL previously had external fixators, evoked sensation of nails boring through the leg. Using a "telescoping" nail, we created the illusion of a nail being removed with corresponding pain relief. (5) Artificial flames produced warmth in the phantom.

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Citations

May 7, 2020·Regional Anesthesia and Pain Medicine·Joel P CastellanosTimothy Furnish
Dec 7, 2020·Pharmacology Research & Perspectives·Benjamin StewartVikas Kotagal
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Henry LoweLorenzo Gordon
Jun 22, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Annegret HagenbergThompson G Robinson
Aug 6, 2021·Frontiers in Psychiatry·Rita KočárováRobin Carhart-Harris
Aug 17, 2021·Frontiers in Neurology·Shariq Mansoor KhanJulie Holland
Sep 8, 2021·European Journal of Pain : EJP·Emma H Beisheim-RyanJaclyn M Sions

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Methods Mentioned

BETA
amputation

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