PMID: 2113806May 1, 1990Paper

Relief of chronic burning pain in Fabry disease with neurotropin

Pediatric Neurology
M InagakiK Takeshita

Abstract

Neurotropin, an extract from the inflamed skin of vaccinia virus-inoculated rabbits, was effective in the relief of sharp or burning pain induced by pyrexia, hot weather, bathing, or exercise in 2 siblings with Fabry disease. Neither neurotropin nor carbamazepine mono-therapy relieved the episodic colicky pain in 1 patient; however, therapy with both drugs eliminated the pain completely. This result suggests that the mechanisms underlying the analgesic actions of both drugs may be complementary in ameliorating the pain of Fabry disease, even though the mechanism underlying the pain has not been clearly elucidated.

References

Jul 1, 1979·Arthritis and Rheumatism·K J Sheth, G C Bernhard
Jun 15, 1977·Acta Neuropathologica·F M ToméG Lenoir
Jun 1, 1979·Japanese Journal of Pharmacology·T KitaS Isida
Jan 1, 1989·Journal of Inherited Metabolic Disease·D Robinson, J M Tager
Apr 1, 1989·The Journal of Clinical Investigation·H S BernsteinR J Desnick
Oct 1, 1988·Japanese Journal of Pharmacology·T HataA Kawabata
Jan 1, 1987·Brain & Development·M InagakiK Takeshita
Aug 1, 1973·Neurology·L A LockmanR J Desnick
Jan 1, 1984·European Neurology·F GemignaniE Govoni

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Citations

Apr 1, 1995·Pediatric Neurology·K E GordonG A Finley
Nov 8, 2001·European Journal of Pharmacology·J MacDermot, K D MacDermot
Dec 20, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L-S RoW-H Chen
Jun 5, 2003·Wiener klinische Wochenschrift·Matthias LorenzGere Sunder-Plassmann
Jan 5, 2002·Journal of Inherited Metabolic Disease·A SessaA Tosoni

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