REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson

Movement Disorders : Official Journal of the Movement Disorder Society
David H BenningerClaudio L Bassetti

Abstract

To evaluate a potential association of REM-sleep behavior disorder (RBD) with gait and postural impairment in Parkinson's disease (PD). Gait difficulties and postural impairment are frequent in PD and are a major cause of disability. Animal studies indicate a key role of the pedunculopontine nucleus (PPN) in gait, postural control, and REM sleep, and also in the pathophysiology of RBD. In humans, such an association has not been investigated. Twenty-six patients with mild-to-moderate PD (13 with polysomnography confirmed and 13 with excluded RBD), and 20 age-matched healthy controls were prospectively investigated. Gait assessment on a treadmill, and static and dynamic posturography were performed. PD patients with RBD do not differ from those without RBD in gait and postural control. Greater severity of PD or prevalence of gait and postural disturbances in the presence of RBD were not found. RBD was not associated with any particular motor phenotype. We found no association of RBD with gait disturbances and postural impairment. Human gait and postural control and RBD appear to depend upon different neuronal circuits.

Associated Clinical Trials

Jul 25, 2014·Salvatore Galati

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Citations

Oct 17, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Eric M McDadeRonald C Petersen
Apr 11, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·David J Burn, Kirstie Anderson
Nov 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Brittany N DuggerTanis J Ferman
Mar 5, 2015·Journal of Neurology·Simon J G Lewis
Aug 10, 2013·Parkinsonism & Related Disorders·Paulo Bugalho, Miguel Viana-Baptista
Mar 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Renato Puppi MunhozLaura Silveira-Moriyama
Nov 27, 2019·Chronobiology International·Luiz Claudio ZulaiEduardo Mendonça Scheeren
Dec 14, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Hui WangYanming Xu
Nov 14, 2018·Frontiers in Neurology·Edoardo Rosario de NataleFranca Deriu

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