REM sleep behavior disorder portends poor prognosis in Parkinson's disease: A systematic review

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Yoon KimBeomseok Jeon

Abstract

REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. Aside from its significance as a predictor of PD, RBD in PD may imply more than merely screaming at night and experiencing sleep fragmentation. To probe its significance as a prognostic factor in PD, we performed a systematic literature review. Analysis of prospective studies reveals baseline RBD confers a higher risk of developing dementia and hallucinations. In cross-sectional studies, RBD is associated with the non-tremor predominant motor phenotype and autonomic dysfunction. Clinical, imaging, and autopsy studies support the presence of dense and diffuse pathology extending beyond the brainstem in PD with RBD. As RBD in PD is associated with a greater disease burden and an increased risk of mortality, we propose the RBD subtype in PD to highlight that RBD may mark a distinct subtype with relatively poor prognosis.

Citations

Jun 18, 2019·Human Brain Mapping·Laura SanderUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 17, 2019·Frontiers in Neurology·Giulio RuffiniJacques Montplaisir
Nov 18, 2019·Clinics in Geriatric Medicine·Priti Gros, Aleksandar Videnovic
Jan 12, 2021·Frontiers in Neuroscience·Laura SanderRegina Schlaeger
Jan 21, 2021·Journal of Personalized Medicine·Francesca AssognaClelia Pellicano
Feb 14, 2021·Journal of Parkinson's Disease·Amir Ashraf-GanjoueiZahra Vahabi
Sep 29, 2020·Parkinsonism & Related Disorders·Young Eun KimHyeo-Il Ma
Mar 18, 2021·Curēus·Maithrayie Kumaresan, Safeera Khan
Mar 25, 2021·Arquivos de neuro-psiquiatria·Pérola de Oliveira, Francisco Cardoso
Apr 27, 2021·Frontiers in Neurology·Ashley BarasaRichard B Dewey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Reinaldo Uribe-San MartínCarlos Juri
© 2022 Meta ULC. All rights reserved