Nov 7, 2018

REM sleep: unique associations with behavior, corticosterone regulation and apoptotic pathways in chronic stress in mice

BioRxiv : the Preprint Server for Biology
Mathieu NolletRaphaelle Winsky-Sommerer

Abstract

One of sleep's putative functions is mediation of adaptation to waking experiences. Chronic stress is a common waking experience, however, which specific aspect of sleep is most responsive, and how sleep changes relate to behavioral disturbances and molecular correlates remain unknown. We quantified sleep, physical, endocrine and behavioral variables and the brain and blood transcriptome in mice exposed to nine weeks of unpredictable chronic mild stress (UCMS). Comparing 46 phenotypical variables revealed that rapid-eye-movement sleep (REMS), corticosterone regulation and coat state were most responsive to UCMS. REMS theta oscillations were enhanced whereas delta oscillations in non-REMS were unaffected. Transcripts affected by UCMS in the prefrontal cortex, hippocampus, hypothalamus and blood were associated with inflammatory and immune responses. A machine learning approach controlling for unspecific UCMS effects identified transcriptomic predictors for specific phenotypes and their overlap. Transcriptomic predictor sets for the inter-individual variation in REMS continuity and theta activity shared many pathways with corticosterone regulation and in particular pathways implicated in apoptosis, including mitochondrial pathway...Continue Reading

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Mentioned in this Paper

Corticosterone Assay
Immune Response
Biochemical Pathway
Prefrontal Cortex
REM1
Regulation of Biological Process
Brain
Oxidative Stress
Oxidative Stress Analysis
Mitochondria-nucleus Signaling Pathway

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis