Remaining Life Expectancy With and Without Polypharmacy: A Register-Based Study of Swedes Aged 65 Years and Older

Journal of the American Medical Directors Association
Jonas W WastessonKristina Johnell

Abstract

To investigate the remaining life expectancy with and without polypharmacy for Swedish women and men aged 65 years and older. Age-specific prevalence of polypharmacy from the nationwide Swedish Prescribed Drug Register (SPDR) combined with life tables from Statistics Sweden was used to calculate the survival function and remaining life expectancy with and without polypharmacy according to the Sullivan method. Nationwide register-based study. A total of 1,347,564 individuals aged 65 years and older who had been prescribed and dispensed a drug from July 1 to September 30, 2008. Polypharmacy was defined as the concurrent use of 5 or more drugs. At age 65 years, approximately 8 years of the 20 remaining years of life (41%) can be expected to be lived with polypharmacy. More than half of the remaining life expectancy will be spent with polypharmacy after the age of 75 years. Women had a longer life expectancy, but also lived more years with polypharmacy than men. Older women and men spend a considerable proportion of their lives with polypharmacy. Given the negative health outcomes associated with polypharmacy, efforts should be made to reduce the number of years older adults spend with polypharmacy to minimize the risk of unwanted ...Continue Reading

References

Jun 14, 2000·Family Practice·L VeehofB M Jong
Oct 30, 2001·American Journal of Epidemiology·S SchneeweissR J Glynn
Jan 17, 2002·European Journal of Clinical Pharmacology·E Simiand-ErdociainJ L Montastruc
Aug 14, 2003·Experimental Gerontology·Klaus Turnheim
Jan 9, 2008·The American Journal of Geriatric Pharmacotherapy·Emily R HajjarJoseph T Hanlon
Jan 9, 2008·European Journal of Clinical Pharmacology·Shaojun ShiUlrich Klotz
Apr 24, 2008·Aging Clinical and Experimental Research·Anna OksuzyanKaare Christensen
Sep 6, 2008·Journal of the American Geriatrics Society·Kevin T BainStephen G Pauker
Jul 9, 2009·The Annals of Pharmacotherapy·Kristina JohnellJohan Fastbom
Sep 25, 2010·Journal of the American Geriatrics Society·Antonio CherubiniJean-Pierre Michel
Dec 3, 2010·BMC Clinical Pharmacology·Bo HovstadiusGöran Petersson
May 31, 2011·Age and Ageing·Denis O'Mahony, Marie N O'Connor
May 24, 2012·International Journal of Public Health·Herman Van OyenJean-Marie Robine
May 8, 2013·Journal of the American Medical Directors Association·Graziano OnderUNKNOWN SHELTER project
Aug 7, 2013·Age and Ageing·Roman Romero-OrtunoCarol Jagger
Oct 1, 2013·Expert Opinion on Drug Safety·Robert L MaherEmily R Hajjar
Aug 12, 2014·Age and Ageing·David MelzerSuzanne H Richards
Nov 25, 2014·BMJ : British Medical Journal·Danijela GnjidicSarah N Hilmer
Dec 18, 2014·Journal of the American Geriatrics Society·Terri R FriedDeanna K Martin
Mar 4, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christina J CharlesworthMichelle C Odden
Apr 15, 2015·Journal of the American Medical Directors Association·Natali JokanovicJ Simon Bell

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Citations

Sep 10, 2016·Age and Ageing·Heidi TaipaleSirpa Hartikainen
Aug 28, 2016·Journal of the American Medical Directors Association·Jonas W WastessonKristina Johnell
Dec 20, 2016·Journal of the American Geriatrics Society·Barbara C WimmerJ Simon Bell
Nov 29, 2016·Journal of the American Geriatrics Society·Jonas W WastessonKaare Christensen
Nov 30, 2018·Journal of the American Geriatrics Society·Stina EkAnna-Karin Welmer
Sep 28, 2018·Geriatrics & Gerontology International·Reinhold KreutzPaul Gellert
Dec 5, 2019·Journal of Women & Aging·Kaishan JiaoMengjia Xu
Jul 9, 2020·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Isabella Ribeiro SilvaRoberta Carvalho de Figueiredo
Apr 17, 2020·European Geriatric Medicine·Laís Lessa Neiva PantuzzaAdriano Max Moreira Reis

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