Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate

Arthritis Care & Research
Reem AltawilJon Lampa

Abstract

To investigate the frequency of remaining pain in early rheumatoid arthritis (RA) after 3 months of treatment with methotrexate as the only disease modifying antirheumatic drug, with a special focus on patients with a good clinical response. The study base was cases reported to a population-based early RA cohort who had followup data from the Swedish Rheumatology Quality Register (n = 1,241). The Disease Activity Score in 28 joints European League Against Rheumatism (EULAR) response criteria were used to evaluate clinical response to treatment as good, moderate, and no response. The primary end point was remaining pain at the 3-months followup visit, defined as pain >20 mm on a 100-mm visual analog scale (VAS). Remaining pain in spite of a EULAR good response at followup was associated with higher baseline disability, using the Health Assessment Questionnaire (adjusted odds ratio [OR] 2.2 [95% confidence interval (95% CI) 1.4-3.4] per unit increase), and less baseline inflammation, using the erythrocyte sedimentation rate (adjusted OR 0.81 [95% CI 0.70-0.93] per 10-mm increase). Similar associations were detected for remaining pain at followup in spite of low inflammatory activity, defined as a C-reactive protein level <10. Inc...Continue Reading

References

Jan 6, 2001·Arthritis and Rheumatism·F Wolfe
May 16, 2003·Nature·Gary S Firestein
May 3, 2006·Journal of Psychosomatic Research·Tanya CovicGraydon Howe
May 6, 2009·Arthritis Research & Therapy·Robert R EdwardsGayle G Page
Apr 20, 2010·Annals of the New York Academy of Sciences·H-G SchaibleG Natura
May 19, 2010·Scandinavian Journal of Rheumatology·C Bengtsson Eira Study Group
Oct 12, 2010·The Journal of International Medical Research·P TaylorA Kavanaugh
Dec 15, 2010·Annals of the Rheumatic Diseases·Saedis SaevarsdottirUNKNOWN SWEFOT Trial Investigators Group
Feb 2, 2011·Nature Reviews. Rheumatology·Robert R EdwardsJennifer A Haythornthwaite
Aug 6, 2011·The Journal of Pain : Official Journal of the American Pain Society·Michael D MitchellLeslie J Crofford
May 5, 2012·Arthritis Care & Research·Daniel F McWilliamsDavid A Walsh
Jan 8, 2013·Current Rheumatology Reports·Yvonne C Lee

❮ Previous
Next ❯

Citations

Jan 28, 2017·Pain·Franziska Denk, Stephen B McMahon
May 29, 2018·European Journal of Pain : EJP·M-A FitzcharlesW Häuser
Jul 3, 2018·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V Chetina, G A Markova
Jul 6, 2018·Scandinavian Journal of Rheumatology·A BilbergK Mannerkorpi
Sep 4, 2017·BMC Musculoskeletal Disorders·Irazú Contreras-YáñezVirginia Pascual-Ramos
May 3, 2018·The Journal of Rheumatology·Patricia L Dobkin, Gilles Boire
Aug 5, 2017·Nature Reviews. Rheumatology·Winfried Häuser, Mary-Ann Fitzcharles
Jun 5, 2020·Scandinavian Journal of Rheumatology·B SvenssonM Andersson
Jun 5, 2019·Arthritis Care & Research·Andrew C HeislerYvonne C Lee
Aug 22, 2018·Current Osteoporosis Reports·Angela Zhang, Yvonne C Lee
May 12, 2019·Clinical Rheumatology·Emmanuel Ruiz-MedranoCesar Alejandro Arce-Salinas
Feb 26, 2021·Scandinavian Journal of Rheumatology·Mec SchelinJ Lampa
Feb 15, 2020·Arthritis Care & Research·Yvonne C LeeKaleb Michaud
Sep 11, 2021·PloS One·Fabiola Gonzalez-PonceUNKNOWN Research Group for the Assessment of Prognosis Biomarkers in Autoimmune Disorders

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here