Remaking memories: reconsolidation updates positively motivated spatial memory in rats.

Learning & Memory
Bethany JonesJean-Marc Fellous

Abstract

There is strong evidence that reactivation of a memory returns it to a labile state, initiating a restabilization process termed reconsolidation, which allows for updating of the memory. In this study we investigated reactivation-dependent updating using a new positively motivated spatial task in rodents that was designed specifically to model a human list-learning paradigm. On Day 1, rats were trained to run to three feeders (List 1) for rewards. On Day 2, rats were trained to run to three different feeders (List 2) in either the same (Reminder condition) or a different (No Reminder condition) experimental context than on Day 1. On Day 3, rats were cued to recall List 1. Rats in the Reminder condition made significantly more visits to List 2 feeders (intrusions) during List 1 recall than rats in the No Reminder condition, indicating that the reminder triggered reactivation and allowed integration of List 2 items into List 1. This reminder effect was selective for the reactivated List 1 memory, as no intrusions occurred when List 2 was recalled on Day 3. No intrusions occurred when retrieval took place in a different context from the one used at encoding, indicating that the expression of the updated memory is dependent upon th...Continue Reading

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Citations

Apr 29, 2014·Psychopharmacology·David ReissAbdel-Mouttalib Ouagazzal
Apr 10, 2012·Neuroscience and Biobehavioral Reviews·Peter S B Finnie, Karim Nader
Nov 27, 2015·Neurobiology of Learning and Memory·Margaret L Schlichting, Alison R Preston
Feb 19, 2013·Current Opinion in Neurobiology·Natalie C Tronson, Jane R Taylor
Mar 10, 2015·Current Opinion in Behavioral Sciences·Margaret L Schlichting, Alison R Preston
Feb 24, 2015·Neurobiology of Learning and Memory·Bethany J JonesJean-Marc Fellous
Jun 20, 2013·Computational Intelligence and Neuroscience·Patrick GreeneJean-Marc Fellous
Dec 8, 2017·The International Journal of Neuropsychopharmacology·Huiwen ZhuLan Ma
Aug 2, 2018·Hippocampus·Marco ContrerasJean-Marc Fellous
Apr 9, 2020·Biological cybernetics·Zhuocheng XiaoJean-Marc Fellous
Apr 19, 2017·Learning & Memory·Angela KlingmüllerTobias Sommer
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Scheila Daiane SchmidtGustavo Provensi
May 4, 2018·Neurobiology of Learning and Memory·Paola Malerba, Maxim Bazhenov
Nov 9, 2017·Journal of Neuroscience Methods·Sam GianelliJean-Marc Fellous

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