Remarkable regression of massive deep vein thrombosis in response to intensive oral rivaroxaban treatment

Thrombosis Journal
Norimichi KoitabashiMasahiko Kurabayashi

Abstract

Deep vein thrombosis (DVT) is a common disease and is associated with pulmonary embolism (PE). Proximal iliofemoral DVT may lead to severe PE and chronic venous insufficiency. The standard therapy for DVT is anticoagulant therapy using heparin and a vitamin K antagonist, but a recent clinical study showed that rivaroxaban, an oral Xa inhibitor, was comparable to standard therapy and had less bleeding complications. Intensive high-dose anticoagulation is recommended during the initial 3 weeks of DVT treatment. The present report describes a case of a 77-year-old male showing a remarkable regression of DVT in response to rivaroxaban treatment within the initial 3 weeks of therapy and who did not experience any adverse events. His DVT was massive and was accompanied by proximal iliofemoral vein thrombus and iliac vein compression syndrome. Rivaroxaban, especially in intensive high-dose treatment, might be a safe and effective therapeutic choice for massive DVT.

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Citations

Dec 20, 2017·Journal of Rural Medicine : JRM·Yusuke WatanabeHideo Fujita
Nov 23, 2018·International Angiology : a Journal of the International Union of Angiology·Pier Luigi AntignaniJawed Fareed
Oct 11, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Huan PengAilan He
Mar 28, 2020·International Angiology : a Journal of the International Union of Angiology·Andrew NicolaidesMichel Perrin
Jul 31, 2019·Jornal Vascular Brasileiro·Polyana Klomfass PiatiJeferson Freitas Toregeani

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Methods Mentioned

BETA
imaging technique

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