Jul 18, 2002

Remarkable substituent effects on antimicrobial activities of 1,3-diorganylimidazolidinium salts

Journal of Chemotherapy
E CetinkayaB Cetinkaya

Abstract

In vitro antibacterial and antifungal activities of a series of 25 diazolidinium salts, 1,3-diorganylimidazolidinium (1), together with 1,3-dialkylpyrimidinium (2), were evaluated against standard strains: Escherichia coli (ATCC 25922), Staphylococcus epidermidis (ATCC 12228), Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Enterobacter cloacae (ATCC 13047), Pseudomonas aeruginosa (ATCC 27853) and Candida albicans (ATCC 10239). Selective and effective antibacterial activity against one gram-negative (P. aeruginosa) and two gram-positive (E. faecalis and S. aureus) bacteria were found in salts 1a, 1i and 1j, in contrast to modest to poor activity observed in the rest of the salts. The enhanced antibacterial activity is clearly linked to the introduction of two bulky mesityl or mesitylbenzyl substituents on the nitrogen atoms of the imidazoline skeleton, while the side chain of the backbone of the molecule has no influence.

  • References1
  • Citations4

References

  • References1
  • Citations4

Citations

Mentioned in this Paper

Gram-Positive Bacteria
Candida albicans
Pseudomonas aeruginosa (antigen)
Structure-Activity Relationship
Thylacodes aureus
Skeletal System
Styrax aureus
Gram-Negative Bacteria
Pseudomonas aeruginosa
Imidazoles

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