Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres

Vaccine
Jaiver E RosasM A Patarroyo

Abstract

Single dose immunisation is a major goal in vaccine design. The purpose of this study was the development of a single dose delivery system for the SPf66 malaria vaccine, based on this antigen's microencapsulation in PLGA microspheres by double emulsion method. Results indicate that a single immunisation in mice and monkeys with the SPf66 malaria vaccine, encapsulated in a mixture of two formulations of PLGA microspheres, induced a remarkably high and long-lasting immune response as assessed by ELISA and Western Blott. This immune response was associated with a good protective capacity in Aotus monkeys, after experimental challenge, indicating that antigen integrity lasted following the microencapsulation process. PLGA biodegradable microspheres thus serve as an effective delivery system for the design of a single dose immunisation vaccine, such as the SPf66 synthetic malaria vaccine.

References

Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M IgartuaJ L Pedraz
Oct 19, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·F ChavesM E Patarroyo
Oct 17, 2006·Parasitology Today·P GravesP Garner

❮ Previous
Next ❯

Citations

Sep 15, 2004·Immunogenetics·Fabio CastilloCarlos Parra-López
Nov 19, 2002·International Journal for Parasitology·Sócrates HerreraMyriam Arévalo-Herrera
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R Sinha, Aman Trehan
Jul 5, 2003·International Journal of Pharmaceutics·A M CarcabosoJ L Pedraz
Oct 19, 2004·Clinical Microbiology Reviews·Rebecca A Cox, D Mitchell Magee
Jul 21, 2011·Journal of Drug Delivery·Aiala SalvadorJosé Luis Pedraz
Nov 4, 2015·Vaccines·Liam PowlesMagdalena Plebanski
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Aug 9, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G PurasJ L Pedraz
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasunari Michinaka, Samir Mitragotri
Oct 31, 2009·International Journal of Pharmaceutics·George MattheolabakisKonstantinos Avgoustakis
Jun 3, 2004·Journal of Biomedical Materials Research. Part a·N StivaktakisK Avgoustakis
Sep 26, 2006·Methods : a Companion to Methods in Enzymology·Magdalena PlebanskiRoss L Coppel
Jul 31, 2008·Expert Review of Vaccines·Lina Wang, Ross L Coppel
Nov 16, 2012·Expert Review of Vaccines·Aiala SalvadorManoli Igartua
Aug 30, 2005·Biochimica Et Biophysica Acta·Konstantina N NikouLeondios Leondiadis
Jul 9, 2005·Veterinary Immunology and Immunopathology·P A Sales-JuniorJ H Patarroyo
Jun 18, 2015·Frontiers in Immunology·Claudia Carvalho-QueirozPhilip T LoVerde
Oct 30, 2015·Human Vaccines & Immunotherapeutics·Mojgan Allahyari, Elham Mohit
Oct 19, 2006·Vaccine·Marc P GirardMarie Paule Kieny
Oct 16, 2004·Memórias do Instituto Oswaldo Cruz·Philip T LoVerdeRosemary Cook
Feb 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Manoli IgartuaJosé Luís Pedraz
Aug 5, 2015·Expert Opinion on Biological Therapy·Hernando CurtidorManuel A Patarroyo
Feb 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilin SadeghiRobert Langer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.