Remdesivir for the Treatment of Covid-19 - Final Report.

The New England Journal of Medicine
John H BeigelACTT-1 Study Group Members

Abstract

Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious. We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only. A total of 1062 patients underwent randomization (with 541 assigned to remdesivir and 521 to placebo). Those who received remdesivir had a median recovery time of 10 days (95% confidence interval [CI], 9 to 11), as compared with 15 days (95% CI, 13 to 18) among those who received placebo (rate ratio for recovery, 1.29; 95% CI, 1.12 to 1.49; P<0.001, by a log-rank test). In an analysis that used a proportional-odds model with an eight-category ordinal scale, the patients who received remdesivir were found to be more likely than those who received place...Continue Reading

References

Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitVincent J Munster
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Feb 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitHeinz Feldmann
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Jul 18, 2020·The New England Journal of Medicine·UNKNOWN RECOVERY Collaborative GroupMartin J Landray
Aug 22, 2020·JAMA : the Journal of the American Medical Association·Christoph D SpinnerUNKNOWN GS-US-540-5774 Investigators

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Citations

Dec 15, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Robert BainMalcolm Brodlie
Jan 2, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniele GeneraliAngelo Pan
Oct 5, 2020·Lancet·Lei-Yun WangJi-Ye Yin
Jan 3, 2021·European Journal of Pharmacology·Aditya K PadhiTimir Tripathi
Oct 5, 2020·Lancet·Yeming WangChen Wang
Oct 5, 2020·Lancet·James H McMahonSharon R Lewin
Aug 7, 2020·International Journal of Antimicrobial Agents·Benjamin DavidoUNKNOWN COVID-19 RPC Team
Nov 26, 2020·Computational and Structural Biotechnology Journal·Desh Deepak SinghDharmendra Kumar Yadav
Dec 15, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Monica FungJennifer Babik
Jan 12, 2021·Advanced Drug Delivery Reviews·Jatin MachhiBhavesh D Kevadiya
Sep 2, 2020·Computational and Structural Biotechnology Journal·Qizhang LiSen Liu
Nov 2, 2020·The Lancet. Respiratory Medicine·Michael A Matthay, B Taylor Thompson
Jan 4, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Krista L LentineMichelle A Josephson
Nov 17, 2020·Patterns·Justin T ReeseChristopher J Mungall
Jan 13, 2021·Irish Journal of Medical Science·Antonio VitielloRaffaele La Porta
Jan 14, 2021·Journal of Biomedical Science·Ioannis P TrougakosMeletios A Dimopoulos
Nov 23, 2020·International Immunopharmacology·Mohadeseh Haji AbdolvahabLeila Farahmand
Jan 14, 2021·Nature Communications·Goran KokicPatrick Cramer
Jan 14, 2021·The Biochemical Journal·George M Burslem
Jan 15, 2021·The Lancet. Respiratory Medicine·Rishi K GuptaUNKNOWN ISARIC4C Investigators
Jan 13, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Wei-Chung ChiouCheng Huang
Dec 18, 2020·Medical Hypotheses·Fotios BarkasEvangelos Liberopoulos
Jan 6, 2021·Computational and Structural Biotechnology Journal·Muhammad Fayyaz Ur RehmanMuhammad Farhan Ul Haque
Oct 6, 2020·EMBO Molecular Medicine·Alexander SimonisJakob J Malin
Oct 19, 2020·European Journal of Medicinal Chemistry·Shakir AhamadSaeed Khan
Nov 24, 2020·British Journal of Clinical Pharmacology·Venkatesh Pilla ReddyAmin Rastomi-Hodjegan
Dec 29, 2020·Journal of Medical Virology·Bin ZhouMasanori Fukushima
Aug 21, 2020·The Lancet Infectious Diseases·Li JiangZulfiqar A Bhutta
Jan 19, 2021·Mathematical Biosciences·Nicole M Gatto, Henry Schellhorn
Nov 23, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·David Y W LeeThomas Efferth
Dec 4, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takatomo HirouchiMasaharu Shinkai
Sep 23, 2020·Annals of Internal Medicine·Brian T GaribaldiAmita Gupta
Oct 31, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi MiikeFukumi Nakamura-Uchiyama
Nov 21, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vladislav IzdaAmr H Sawalha
Oct 24, 2020·Journal of Clinical Epidemiology·Van Thu NguyenUNKNOWN COVID-NMA Consortium Team
Dec 7, 2020·EBioMedicine·Stanislas Grassin-DelyleUNKNOWN Garches COVID-19 Collaborative Group RECORDS Collaborators and Exhalomics® Collaborators
Dec 23, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kyungmin HuhJaehun Jung

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