Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.

Lancet
Yeming WangChen Wang

Abstract

No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models. We did a randomised, double-blind, placebo-controlled, multicentre trial at ten hospitals in Hubei, China. Eligible patients were adults (aged ≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection, with an interval from symptom onset to enrolment of 12 days or less, oxygen saturation of 94% or less on room air or a ratio of arterial oxygen partial pressure to fractional inspired oxygen of 300 mm Hg or less, and radiologically confirmed pneumonia. Patients were randomly assigned in a 2:1 ratio to intravenous remdesivir (200 mg on day 1 followed by 100 mg on days 2-10 in single daily infusions) or the same volume of placebo infusions for 10 days. Patients were permitted concomitant use of lopinavir-ritonavir, interferons, and corticosteroids. The primary endpoint was...Continue Reading

Citations

May 28, 2020·The New England Journal of Medicine·Jason D GoldmanUNKNOWN GS-US-540-5773 Investigators
May 29, 2020·Journal of Biomolecular Structure & Dynamics·Subhomoi Borkotoky, Manidipa Banerjee
May 19, 2020·Expert Opinion on Investigational Drugs·Denise BattagliniPatricia Rieken Macedo Rocco
May 10, 2020·Stem Cells and Development·Vikram SenguptaNicholas Bremer
May 12, 2020·The Journal of Clinical Investigation·Evelyne BischofSabra L Klein
Jun 9, 2020·European Heart Journal·J M PericàsUNKNOWN Hospital Clínic Cardiovascular Infections Study Group
May 28, 2020·Journal of Biomolecular Structure & Dynamics·Aditya Arya, Vivek Dhar Dwivedi
May 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kate ChildsChris Taylor
May 30, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Miranda DaviesSaad Shakir
May 21, 2020·Allergy·Sergio Bonini, Giuseppe Maltese
Jun 4, 2020·Journal of Medical Virology·Karolina AkinosoglouCharalampos Gogos
Jun 24, 2020·Microbial Biotechnology·Harald Brüssow
Jun 25, 2020·JAMA : the Journal of the American Medical Association·Ameet SarpatwariAaron S Kesselheim
Jun 5, 2020·Physiological Reviews·Stefano RomagnoliPierangelo Geppetti
Jun 13, 2020·Expert Review of Respiratory Medicine·Arafat HussainAnant Mohan
Jun 20, 2020·Médecine sciences : M/S·Dylan JuckelSandrine Belouzard
Jun 25, 2020·Emerging Microbes & Infections·Chasity D AndrewsRachel A Liberatore
Jun 24, 2020·Frontiers in Public Health·Raghuvir KeniKrishnadas Nandakumar
Jul 9, 2020·Alimentary Pharmacology & Therapeutics·Anand V KulkarniDuvvuru Nageshwar Reddy
Jul 9, 2020·Future Medicinal Chemistry·Shiyong FanWu Zhong
Jul 10, 2020·Critical Reviews in Clinical Laboratory Sciences·Marco CiottiSergio Bernardini
Jul 10, 2020·Irish Journal of Psychological Medicine·G Gulati, B D Kelly
Jun 27, 2020·JMIR Public Health and Surveillance·Guosheng YinHuaqing Jin
May 30, 2020·International Journal of Molecular Medicine·George Mihai NitulescuAristidis Tsatsakis
Jul 16, 2020·AACN Advanced Critical Care·Lolade S Bakare, John M Allen
Jul 18, 2020·The Medical Journal of Australia·Irani ThevarajanBenjamin C Cowie
Jul 18, 2020·Clinical Trials : Journal of the Society for Clinical Trials·Lori E DoddThomas Jaki
Jul 8, 2020·Journal of Medical Virology·Yanyan WangLijun Rong
Jun 24, 2020·Current Medicine Research and Practice·Meda VenkatasubbaiahSuggala V Satyanarayana
Jul 16, 2020·Journal of Medical Virology·Viveksandeep Thoguluva ChandrasekarMayur Ramesh
Jul 8, 2020·Viruses·Jennifer SantosArwen B L Declan
Aug 1, 2020·BMJ : British Medical Journal·Bram RochwergGordon Guyatt

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Methods Mentioned

BETA
bronchoalveolar
lavages
PCR
bronchoalveolar lavages

Clinical Trials Mentioned

NCT04257656

Software Mentioned

SAS

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