Remifentanil for Carboprost-Induced Adverse Reactions During Cesarean Delivery Under Combined Spinal-Epidural Anesthesia

Frontiers in Pharmacology
Chang-Na WeiQing-He Zhou

Abstract

Carboprost may induce adverse reactions when used to treat postpartum hemorrhage. We aimed to explore the effects of intravenous infusion of low-dose remifentanil to prevent such reactions. We enrolled parturient patients scheduled for elective cesarean section. Anesthesiologist administered combined spinal epidurals at the L3/4 interspace, with 0.5% hyperbaric bupivacaine subarachnoid space injections (1.5-2.5 ml). We randomly divided parturient patients, administered carboprost during surgery, into the remifentanil group (group R) and the control group (group C). Patients in group R received an intravenous target-controlled infusion of remifentanil (target effect-site concentration, 1.5 ng/ml) simultaneously with a carboprost tromethamine injection (250 µg). Patients in group C received a normal saline infusion with carboprost. We recorded and analyzed the incidence of carboprost-related adverse reactions (vomiting, nausea, chest congestion, flushing, hypertension, tachycardia, cough, and shivering), and assessed patient comfort using a numerical rating scale ([NRS], on which 0 was very uncomfortable and 10 was very comfortable). After applying inclusion and exclusion criteria, we conducted statistical analysis of the data fr...Continue Reading

References

Jul 1, 1986·American Journal of Perinatology·L Buttino, T J Garite
Jun 7, 2005·International Journal of Obstetric Anesthesia·M Balki, J C A Carvalho
Jun 15, 2007·Advances in Therapy·Nurten KayacanM Erman
Nov 10, 2007·Anaesthesia·R KomatsuC C Apfel
Apr 7, 2009·Regulatory Peptides·Peter Holzer
Mar 20, 2010·Anesthesia and Analgesia·Brian T BatemanLisa R Leffert
Jun 15, 2010·British Journal of Anaesthesia·M NakasujiS H Suh
Mar 19, 2014·International Journal of Obstetric Anesthesia·K CheesmanJ Douglas
Oct 21, 2014·Anesthesia and Analgesia·Anne-Sophie Ducloy-BouthorsEvelyn Lockhart
Jan 15, 2015·American Journal of Obstetrics and Gynecology·Alexander J ButwickBrian T Bateman
Oct 4, 2015·Journal of Clinical Anesthesia·Hiroshi HoshijimaHiroshi Nagasaka
Dec 8, 2015·Hematology·Evelyn Lockhart
Jul 28, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Giel van StralenChantal W P M Hukkelhoven
Oct 23, 2016·Journal of Anesthesia·Yayoi OhashiMrinalini Balki
Feb 17, 2017·International Journal of Obstetric Anesthesia·A AhiskaliogluH A Alici
Mar 3, 2017·Emergency Medicine Journal : EMJ·Magdalena KisilewiczChristian Vaillancourt
Jun 9, 2018·Journal of Thrombosis and Haemostasis : JTH·D D C A HenriquezJ G van der Bom

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Methods Mentioned

BETA
cesarean sections
cesarean section
sedation

Software Mentioned

SPSS Statistics

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