PMID: 20650046Jul 24, 2010Paper

Remifentanil in combination with ketamine versus remifentanil in spinal fusion surgery--a double blind study

International Journal of Clinical Pharmacology and Therapeutics
B A HadiR Zelkó

Abstract

This study is aimed at conducting a program for two different anesthetic methods used during a spinal fusion surgery to ensure better intra-operative hemodynamic stability and post-operative pain control. A prospective, randomized, double blind study in patients scheduled for spinal fusion surgery, who were randomly allocated to two groups, G1 and G2, (n = 15 per group), class I-II ASA, was carried out. Both groups received pre-operatively midazolam, followed intra-operatively by propofol, sevoflurane, atracurium, and either remifentanil infusion 0.2 microg/kg/min (G1), or the same dose of remifentanil infusion and low doses of ketamine infusion 1 microg/kg/min (G2) anesthetics, antidote medication and post-operative morphine doses. HR, MAP, vital signs, surgical bleeding, urine output, duration of surgery and duration of anesthesia were recorded. In a 24-h recovery period in a post-anesthesia care unit (PACU) the recovery time, the first pain score and analgesic requirements were measured. Intra-operative HR and arterial BP were significantly less (p < 0.05) in G1 as compared to G2. In the PACU the first pain scores were significantly less (p < 0.05) in G2 than in G1. The time for the first patient analgesia demand dose was gr...Continue Reading

Citations

Jul 21, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kevin LaskowskiHyun J Lim
Oct 28, 2011·Regional Anesthesia and Pain Medicine·Sonal SharmaMarcel E Durieux
Aug 21, 2012·Anesthesiology Clinics·Lawrence T LaiAudrée A Bendo
Mar 16, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gary Andolfatto, Elaine Willman
May 7, 2011·Journal of Clinical Pharmacy and Therapeutics·M HuB Tomlinson
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Bushra A HadiRomána Zelkó
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Neil MartinLucy R Wedderburn
Jan 8, 2015·International Journal of Clinical Pharmacy·Bushra Abdul Hadi, Saleh M Sbeitan

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