Remifentanil-induced alterations in neutrophil numbers after surgery

JA Clinical Reports
Toshiichro InagiAtsuhiro Sakamoto

Abstract

Neutrophils are the first line of defense against invasive microorganisms during and after surgery. There is a possibility that different opioid analgesics used during surgery have different effects on the leucocyte count. We retrospectively analyzed the numbers of leucocytes, neutrophils, and lymphocytes just after surgery in patients who received remifentanil-based anesthesia and those who received fentanyl-based anesthesia.In female patients who underwent modified mastectomy or simple mastectomy with resection of a lymph node(s) or with biopsy of a sentinel lymph node(s) between January 2010 and December 2013 (n = 83), propensity score pairwise matching was performed according to the patient's age and procedure, and forty patients (Remifentanil group and Fentanyl group;n = 20 each) were analyzed. Postoperative numbers of leucocytes and neutrophils were significantly lower in patients who received remifentanil-based anesthesia than in those who received fentanyl-based anesthesia (p = 0.03,p = 0.014; leucocytes and neutrophils, respectively). The increases in the numbers of leucocytes and neutrophils were significantly lower in the patients in the remifentanil group (p = 0.009,p = 0.0046; increase in leucocytes and neutrophils...Continue Reading

References

Mar 15, 2000·Surgery·K OgawaT Kajiwara
May 19, 2001·International Immunopharmacology·P SacerdoteM Bianchi
Nov 25, 2003·British Journal of Anaesthesia·A J CroninR H Bonneau
Dec 27, 2005·The Journal of Surgical Research·Masayasu IwaseMasao Nagumo
Jul 14, 2010·Trends in Immunology·Charlotte SummersEdwin R Chilvers
Oct 11, 2011·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Won Ho KimMyung Hee Kim
Mar 14, 2013·Immunopharmacology and Immunotoxicology·Jeong HyejinKwak Sanghyun
Feb 1, 2012·Current Therapeutic Research, Clinical and Experimental·Lutfiye Pirbudak CocelliHakan Karadasli

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Citations

Feb 26, 2020·Current Treatment Options in Oncology·Jaya Amaram-DavilaAkhila Reddy

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Methods Mentioned

BETA
biopsy

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