Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis

Journal of Anesthesia
Shigeru MaedaTakuya Miyawaki

Abstract

Neuronal inflammation is caused by systemic inflammation and induces cognitive dysfunction. IL-6 plays a crucial role in therapies for neuronal inflammation and cognitive dysfunction. Remifentanil, an ultra-short-acting opioid, controls inflammatory reactions in the periphery, but not in the brain. Therefore, the anti-inflammatory effects of remifentanil in neuronal tissue and the involvement of cAMP in these effects were investigated in the present study. Mice were divided into 4 groups: control, remifentanil, LPS, and LPS + remifentanil. Brain levels of pro-inflammatory cytokine mRNA, and serum levels of corticosterone, catecholamine and IL-6 were measured in the 4 groups. The co-localization of IL-6 and astrocytes in the mouse brain after the LPS injection was validated by immunostaining. LPS and/or remifentanil-induced changes in intracellular cAMP levels in cultured glial cells were measured, and the effects of cAMP on LPS-induced IL-6 mRNA expression levels were evaluated. Remifentanil suppressed increase in IL-6 mRNA levels in the mouse brain, and also inhibited the responses of plasma IL-6, corticosterone, and noradrenaline in an inflammatory state. In the hypothalamus, IL-6 was localized in the median eminence, at whic...Continue Reading

References

Jul 13, 2002·Annals of the New York Academy of Sciences·Farideh Eskandari, Esther M Sternberg
Jan 13, 2004·Physiological Reviews·Kjetil Taskén, Einar Martin Aandahl
Oct 3, 2008·Neuropsychiatric Disease and Treatment·Shigeru MaedaTakuya Miyawaki
May 23, 2009·Nature Reviews. Immunology·Serge Rivest
Sep 17, 2009·Molecular Biology Reports·Zhang ZongzeWang Yanlin
Apr 20, 2010·Acta Anaesthesiologica Scandinavica·J L RudolphE R Marcantonio
Jun 22, 2010·The Journal of Biological Chemistry·Nan GaoTakashi Okamoto
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Nov 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andy Y WenLloyd S Miller
May 18, 2011·Neuroscience Letters·António Rei FidalgoDaqing Ma
Jun 21, 2011·Journal of Neuroinflammation·Kumiko TanabeHiroki Iida
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Sarah GerloGuy Haegeman
Nov 9, 2012·International Journal of Biological Sciences·María ErtaJuan Hidalgo
Apr 24, 2013·BMC Gastroenterology·Steven S C ChoClaudia A Nold-Petry
Feb 13, 2014·Brain, Behavior, and Immunity·Iris B HovensBarbara L van Leeuwen
Jul 30, 2014·International Journal of Molecular Medicine·Kumiko TanabeHiroki Iida
Nov 5, 2014·Frontiers in Endocrinology·Miriam CapriClaudio Franceschi
Sep 26, 2015·European Journal of Pharmacology·Marta ZielińskaJakub Fichna
Oct 31, 2015·Intensive Care Medicine Experimental·Monique MichelsFelipe Dal-Pizzol

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Citations

May 10, 2019·Frontiers in Neurology·Clément ChollatFabien Tourrel

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