Remimazolam for anaesthesia or sedation.

Current Opinion in Anaesthesiology
J Robert Sneyd, Ann E Rigby-Jones

Abstract

Anaesthesia and sedation are ubiquitous in contemporary medical practice. Developments in anaesthetic pharmacology are targeted on reducing physiological disturbance whilst maintaining or improving titrateability, recovery profile and patient experience. Remimazolam is a new short-acting benzodiazepine in the final stages of clinical development. Clinical experience with remimazolam comprises volunteer studies and a limited number of clinical investigations. In addition, laboratory investigations explore the implications of its 'soft drug' pharmacology. Remimazolam provides effective procedural sedation with superior success rates and recovery profile when compared to midazolam. Comparisons with propofol are required. Preliminary studies suggest potential for using remimazolam as the hypnotic component of general anaesthesia. Definitive studies are awaited. As a benzodiazepine, remimazolam could be evaluated as an anticonvulsant and for intensive care sedation.

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Citations

Mar 10, 2021·Expert Review of Clinical Pharmacology·Weiyun ChenYuguang Huang
Feb 22, 2021·European Journal of Medicinal Chemistry·Shuo YuanBin Yu
Apr 18, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Gizem Kayki-Mutlu, Martin C Michel
Jul 2, 2021·Drugs·Arnold Lee, Matt Shirley
Aug 7, 2021·Frontiers in Pharmacology·Gavin J Kilpatrick
Aug 20, 2021·Paediatric Anaesthesia·Jacob Karlsson, Gianluca Bertolizio
Oct 17, 2021·Journal of Clinical Pharmacy and Therapeutics·Shuoya ZhangYun Xiao
Oct 6, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Yulin ZhuShujun Shang

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