Remission induction therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines

Cancer Treatment Reviews
M RongheE J Estlin

Abstract

Remission induction therapy with vincristine, a corticosteroid, L-asparaginase and an anthracycline has been the mainstay of the initial phase of treatment for childhood acute lymphoblastic leukaemia (ALL) for the past 25 years. The speed and depth of the early response to remission induction therapy has become an important determinant of the intensity of subsequent therapy in many protocols worldwide. Moreover, the detection of significant levels of minimal residual disease at the end of remission induction may have an important bearing on subsequent outcome. Although these clinical observations may reflect, in part, the inherent sensitivity of lymphoblasts to remission induction therapy, the pharmacology of these agents in relation to childhood ALL may also play an important part in early response to therapy. In-vitro studies of human leukaemia cell lines indicate that both the extracellular fluid concentration and duration of exposure to vincristine and anthracyclines are important determinants of cytotoxicity. For L-asparaginase and corticosteroids, the cellular and molecular pharmacological determinants of chemosensitivity have been partially characterized, but further work is needed in this area. The clinical pharmacology...Continue Reading

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·T ShimizuH Mikawa
Oct 1, 1990·Clinical Pharmacology and Therapeutics·M R HillA M Brenner
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·I ChoonaraI Lewis
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·C R PinkertonM Brunat-Mentigny
May 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E KokenbergB Löwenberg
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·P A SpethC Haanen
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·P A SpethC Haanen
Feb 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M BalisD G Poplack
May 1, 1966·Clinical Pharmacology and Therapeutics·M KaronJ Blom
May 30, 1967·Biochimica Et Biophysica Acta·J D Broome, J H Schwartz
Apr 1, 1995·Medical and Pediatric Oncology·S S de GraafD R Uges
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S P DibenedettoL Lo Nigro
Jun 1, 1994·Molecular Endocrinology·E B Thompson
Sep 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B L AsselinH J Cohen
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J VeermanA Van der Does-Van der Berg
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ItoD Campana
Sep 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GentiliG Masera
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J BoosH Jürgens
May 1, 1997·The American Journal of Physiology·R G HutsonM S Kilberg
Oct 13, 1998·Critical Reviews in Oncology/hematology·H J Müller, J Boos
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M H WooM V Relling
Aug 24, 1999·Cancer Chemotherapy and Pharmacology·C E GiddingS S de Graaf
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M H WooM V Relling
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L SchwartzS E Sallan
Sep 1, 1956·Cancer·C B HYMAN, P STURGEON

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Citations

May 15, 2009·Free Radical Biology & Medicine·Richard D BrownGuy C Brown
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·C ThenmozhiP Sampathkumar
Oct 4, 2002·Hematological Oncology
Sep 20, 2007·Journal of Advanced Nursing·Eva Ericson-Lidman, Gunilla Strandberg
Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilaria ChiocchioFerruccio Poli

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