Remission of extensive intrahepatic metastasis by C-arm computed tomography guided chemoembolization in uveal melanoma

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Cord SunderkötterFrank K Wacker

Abstract

As soon as uveal melanoma has metastasized to the liver, response rates to systemic chemotherapy are low. It can be improved by development of special locoregional procedures. A 24-year-old woman suffered from inoperable hepatic metastases which grew to life-endangering size despite both systemic chemotherapy with gemcitabine/treosulfan and conventional intrahepatic chemoembolization with fotemustine and starch particles. We subsequently performed two angiographic C-arm CT-guided, superselective chemoembolizations of the hepatic arteries feeding the tumor, using cisplatin, starch microspheres and ethiodized oil. Following this treatment, no vital tumor tissue was detectable by MRI. This remission lasted for more than 6 months and the patient's quality of life was good. A subsequent local relapse could not be treated with chemoembolization because of thrombosis of the portal vein due to tumor compression. And the patient died 20 months after first detection of metastases. However, the selective angiographic C-arm CT-guided chemoembolization resulted in prolongation of life with good quality despite the advanced stage of the disease.

References

Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S LeyvrazL Zografos
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
May 26, 2004·Journal of Cancer Research and Clinical Oncology·P TerheydenJ C Becker
Feb 14, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S PetersS Leyvraz
Dec 7, 2007·Journal of Vascular and Interventional Radiology : JVIR·Michael J WallaceMarshall E Hicks
Mar 22, 2008·AJR. American Journal of Roentgenology·Bernhard C MeyerFrank K Wacker

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