Remission of Intermediate Uveitis: Incidence and Predictive Factors

American Journal of Ophthalmology
John H KempenSystemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group

Abstract

To evaluate the incidence of remission among patients with intermediate uveitis; to identify factors potentially predictive of remission. Retrospective cohort study. Involved eyes of patients with primary noninfectious intermediate uveitis at 4 academic ocular inflammation subspecialty practices, followed sufficiently long to meet the remission outcome definition, were studied retrospectively by standardized chart review data. Remission of intermediate uveitis was defined as a lack of inflammatory activity at ≥2 visits spanning ≥90 days in the absence of any corticosteroid or immunosuppressant medications. Factors potentially predictive of intermediate uveitis remission were evaluated using survival analysis. Among 849 eyes (of 510 patients) with intermediate uveitis followed over 1934 eye-years, the incidence of intermediate uveitis remission was 8.6/100 eye-years (95% confidence interval [CI], 7.4-10.1). Factors predictive of disease remission included prior pars plana vitrectomy (PPV) (hazard ratio [HR] [vs no PPV] = 2.39; 95% CI, 1.42-4.00), diagnosis of intermediate uveitis within the last year (HR [vs diagnosis >5 years ago] =3.82; 95% CI, 1.91-7.63), age ≥45 years (HR [vs age <45 years] = 1.79; 95% CI, 1.03-3.11), female...Continue Reading

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Citations

Jul 18, 2018·Ocular Immunology and Inflammation·Hiroshi GotoShigeaki Ohno
Aug 31, 2018·PloS One·Jin-Woo KwonYang Kyung Cho
Apr 4, 2017·The Journal of Rheumatology·Gabriele SimoniniRolando Cimaz
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Mar 14, 2021·American Journal of Ophthalmology·Caroline L MinkusUNKNOWN Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Research Group

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