Remission of nonparaneoplastic autoimmune retinopathy after minimal steroid treatment

Retinal Cases & Brief Reports
Lulu L C D BursztynAlain A Proulx

Abstract

To describe the clinical findings in a patient demonstrating recovery from nonparaneoplastic autoimmune retinopathy after a minimal course of steroid treatment. Clinical presentation was documented, and paraclinical tests were obtained using Humphrey automated perimetry for visual fields, Western blotting for antiretinal antibodies, and electroretinography for evaluation of rod and cone function. Initial presentation revealed marked visual field deficits, electroretinographic dysfunction, and the presence of α-enolase autoantibodies. After a brief course of oral corticosteroids, the patient demonstrated improvement in visual fields, disappearance of α-enolase autoantibodies, partial recovery of the cone on-response, and complete recovery of the rod response. This case is distinguished from previous reports by the rapidity and degree of recovery, the brevity of treatment required, and the unique electroretinographic recovery pattern with concomitant disappearance of α-enolase autoantibodies. These findings suggest a pathologic role for α-enolase autoantibodies in autoimmune rod bipolar cell dysfunction. Identification of other cases exhibiting such improvements and associated autoantibody activity may expand our understanding of...Continue Reading

References

Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·J J HooksB Detrick
Apr 15, 2008·Seminars in Immunopathology·John R Heckenlively, Henry A Ferreyra
Jan 1, 2008·Retinal Cases & Brief Reports·Linda S KimGerald A Fishman
Apr 15, 2009·Archives of Ophthalmology·Henry A FerreyraJohn R Heckenlively
Aug 1, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·T BraithwaiteA Tufail

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Citations

Aug 23, 2020·Indian Journal of Ophthalmology·Parthopratim Dutta MajumderAniruddha Agarwal
Jul 24, 2021·Scientific Reports·Aulia Rahmi PawestriAdisak Trinavarat

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