Remission of proteinuria in primary glomerulonephritis: we know the goal but do we know the price?

Nature Clinical Practice. Nephrology
David Philibert, Daniel C Cattran

Abstract

Membranous nephropathy, focal segmental glomerulosclerosis and IgA nephropathy are the most commonly recognized types of primary glomerulonephritis that progress to end-stage renal disease. Persistent proteinuria is a major determinant of such progression. Reduction of proteinuria slows progression of renal disease and improves renal survival, but many of the agents used to reduce proteinuria carry a considerable risk of toxicity. The assessment of benefit versus risk of these medications can be further complicated by the temporal disconnect between the onset of benefit and of serious adverse events. In addition, relapses are common in these disorders and there is often a need for retreatment. Such retreatment might lead to repeated and/or prolonged drug exposure and to the oversight or underestimation of the cumulative dose of these agents because of the potentially extended interval between relapses. Consequently, it is very important to constantly review each patient's status and take into account their age, comorbid conditions and cumulative drug exposure when assessing treatment options. The potentially delayed development of adverse events also emphasizes the need for long-term surveillance of patients who receive immunos...Continue Reading

References

Dec 1, 1991·Kidney International·S RekolaH Bucht
Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlamartineF Berthoux
Apr 8, 1988·JAMA : the Journal of the American Medical Association·S A Rivkees, J D Crawford
Apr 12, 1984·The New England Journal of Medicine·C PonticelliT Volpini
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J J RydelM M Schwartz
Nov 3, 1994·The New England Journal of Medicine·J V DonadioK E Holley
Jun 1, 1993·Kidney International·C PonticelliF Locatelli
Nov 1, 1996·Journal of the American Academy of Dermatology·N J LoweM T Grabie
Nov 14, 1997·Journal of the American Society of Nephrology : JASN·J J Dillon
Apr 8, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W VleemingD J de Wildt
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D C Cattran, P Rao
Aug 26, 1998·QJM : Monthly Journal of the Association of Physicians·A J BrantenJ F Wetzels
Jun 3, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B J Laluck, D C Cattran
Aug 5, 1999·Kidney International·B E Marx, M Marx
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C PonticelliA Baroli
Aug 30, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J L WeiR O Gustafson
Mar 22, 2001·Kidney International·D C CattranUNKNOWN North America Nephrotic Syndrome Study Group
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L P BartosikD C Cattran
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Francis W Ballardie, Ian S D Roberts
Jan 25, 2003·The Journal of Investigative Dermatology·Carle F PaulLouis Dubertret
Feb 13, 2003·Toxicology·Thierry Vial, Jacques Descotes
Feb 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bertram L KasiskeArthur J Matas
Mar 5, 2003·Nephron. Clinical Practice·Dimitrios S GoumenosColin B Brown
May 23, 2003·Journal of the American Society of Nephrology : JASN·Manuel PragaEduardo Hernández
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Piero RuggenentiGiuseppe Remuzzi
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Claudio PozziFrancesco Locatelli
Apr 17, 2004·Kidney International·Yuansheng XieFumitake Gejyo
Jun 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peggy W G du Buf-Vereijken, Jack F M Wetzels
Aug 6, 2004·The New England Journal of Medicine·Biff F Palmer
Aug 26, 2004·Kidney International·Pierre SimonNathalie Rioux

❮ Previous
Next ❯

Citations

Jun 19, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·An-Hang YangWu-Chang Yang
Feb 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julia M Hofstra, Jack F M Wetzels
Oct 27, 2010·PloS One·Heather N ReichMatthias Kretzler
Jul 12, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shih-Yin ChenFuu-Jen Tsai
Oct 21, 2014·PloS One·Makoto YamaguchiShoichi Maruyama
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Cattran, Paul Brenchley
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Alain Meyrier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Heather ReichToronto Glomerulonephritis Registry
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
James V DonadioDiana M Rademcher
© 2022 Meta ULC. All rights reserved