PMID: 8952790Oct 1, 1996Paper

Remission of severe hypoglycemic incidents in young diabetic children treated with subcutaneous infusion

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
N Tubiana-RufiP Czernichow

Abstract

Conventional insulin therapy for diabetes mellitus can be inadequate for controlling glycemia in young patients in whom the risk of hypoglycemia is particularly high. A retrospective study comparing all the children under 6 years of age treated in our department by continuous subcutaneous insulin infusion (group P, n = 10, mean age: 3.7 years) to 17 children with conventional insulin therapy (group C, mean age: 5.1 years) was conducted during a mean period of 2 years. Mean insulin doses, HbAlc, pre-prandial and daily glycemic levels, measured at 0, 3, 6, 12, 18 and 24 months, did not differ significantly between both groups. Mean HbAlc levels remained < or = 8% in the two groups. There was no episode of severe hypoglycemia in group P vs ten episodes in group C (P < 0.05); this benefit was confirmed in those six children belonging to group P who had previously followed a conventional therapy: 11 episodes during the conventional period vs 0 episode during the pump period (P < 0.05). Nine out of ten families were very satisfied with the treatment by pump mainly because of a more comfortable life style and a reduction of parents' anxiety due to disappearance of severe hypoglycemias. The insulin pump therapy had some limits: cutaneo...Continue Reading

Citations

Jun 16, 2006·Pediatric Diabetes·Ragnar Hanas, Johnny Ludvigsson
Dec 13, 2006·Reviews in Endocrine & Metabolic Disorders·William V TamborlaneStuart A Weinzimer
Nov 20, 1998·Acta Paediatrica. Supplement·W KiessU Nietzchmann
Dec 10, 1999·Diabetes/metabolism Research and Reviews·F R KaufmanP Pitukcheewanont
Mar 29, 2003·Diabetes Care·Jill Weissberg-BenchellRoopa Seshadri
May 6, 2005·Treatments in Endocrinology·William V TamborlaneJoAnn H Ahern
Apr 15, 2010·Diabetes Technology & Therapeutics·Ewa PańkowskaMiroslawa Urban
Jan 19, 2016·Soins. Pédiatrie, puériculture·Hélène Crosnier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

al-Maghrib al-ṭibbī. Maroc médical
H Beck
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
N Tubiana-Rufi
© 2021 Meta ULC. All rights reserved