PMID: 8606630Mar 1, 1996Paper

Remission of systematic lupus erythematosus

Medicine
C DrenkardD Alarcón-Segovia

Abstract

The occurrence and characteristics of remissions in patients with systematic lupus erythematosus (SLE) have not been determined. We therefore studied this in a cohort of 667 patients and found that 156 patients had achieved at least 1 period of 1 year or more of treatment-free clinical remission. This represents an incidence density of 0.028 new cases/person/year. Remission occurred within the first 2 years of disease in 62 patients. The mean duration of first remission was 4.6 years (range, 1-21 yr), and 81 patients were still in the initial remission up until cutoff time. Half of the remaining 75 patients who flared after achieving remission have not entered again in remission. Twenty-six of the 38 patients who did remained in remission, and the remaining 12 had subsequent flares and remissions. Treatment-free remission accounted for a mean of 5.8 years, corresponding to half the time of follow-up. Remission was not limited to patients with mild disease: at least 41 patients achieved remission despite renal involvement, 19 had had neuropsychiatric lupus, 15 had had thrombocytopenia, and 8 had had hemolytic anemia. We also found that the longer the time lapse between the initial manifestation and the diagnosis of SLE, the less...Continue Reading

References

Apr 1, 1978·Arthritis and Rheumatism·S J RiveroD Alarcón-Segovia
Oct 1, 1975·Annals of the Rheumatic Diseases·T Gibson, A R Myers
Apr 1, 1992·Seminars in Arthritis and Rheumatism·D Alarcón-SegoviaJ Cabiedes
Jun 1, 1982·The Journal of Clinical Investigation·J Alcocer-Varela, D Alarcón-Segovia
Feb 1, 1982·Annals of the Rheumatic Diseases·E C TozmanD D Gladman
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Dec 1, 1994·Journal of Autoimmunity·C AlvaradoD Alarcon-Segovia
Nov 6, 1954·Journal of the American Medical Association·P A TUMULTY
Aug 1, 1956·Annals of Internal Medicine·E L DUBOIS

❮ Previous
Next ❯

Citations

Jan 1, 2000·Arthritis and Rheumatism·S G BarrM Petri
Feb 14, 2004·Medical Hypotheses·Eftim Adhami
Jun 3, 2004·The Journal of Experimental Medicine·David M Tarlinton, Philip D Hodgkin
Oct 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriella MoroniClaudio Ponticelli
Apr 18, 2014·Annals of the Rheumatic Diseases·Ronald F van VollenhovenMatthias Schneider
Aug 9, 2005·Hematology·Massimo Franchini, Dino Veneri
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Murray B Urowitz, Dafna D Gladman
Dec 10, 2014·Expert Review of Clinical Immunology·Gabriella Moroni, Claudio Ponticelli
Feb 10, 2007·Autoimmunity Reviews·Alejandro Ruiz-Argüelles, Luis Llorente
Jun 4, 2002·Best Practice & Research. Clinical Rheumatology·David Hermosillo-Romo, Robin L Brey
Sep 2, 2000·Journal of Autoimmunity·D Alarcón-SegoviaA R Villa
May 6, 2016·Journal of Nephrology·Gabriella MoroniClaudio Ponticelli
Nov 12, 2015·Arthritis Care & Research·Carmen V Medina-QuiñonesDavid Isenberg
Oct 4, 2016·Arthritis Care & Research·Ari PolachekMurray B Urowitz
Apr 5, 2013·Lupus·C RosarioY Shoenfeld
Jan 1, 1997·Lupus·C DrenkardD Alarcón-Segovia
Sep 17, 2014·The Journal of Rheumatology·Jose A Gómez-PuertaRicard Cervera
Aug 3, 2014·The Journal of Rheumatology·Amanda J SteimanDafna D Gladman
Mar 1, 2017·Lupus Science & Medicine·Noémi GyöriMichelle Petri
Feb 4, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriella MoroniClaudio Ponticelli
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Gabriella MoroniClaudio Ponticelli
Jun 17, 2016·Nature Reviews. Disease Primers·Arvind KaulGraham Hughes
Aug 6, 2019·International Journal of Rheumatic Diseases·Giuseppe A RamirezEnrica P Bozzolo
Aug 26, 2016·Annals of the Rheumatic Diseases·Theresa R WilhelmMichelle Petri
Jul 14, 2016·Clinical Rheumatology·Manuel F Ugarte-GilGraciela S Alarcón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.