PMID: 8593123Oct 1, 1995Paper

Remnant particles and their metabolism

Baillière's Clinical Endocrinology and Metabolism
S Eisenberg, E Sehayek

Abstract

The data described in this chapter demonstrate that the metabolic control of processes responsible for the formation, uptake and clearance of remnant particles is considerably more complex than previously believed. It now appears that several interacting reactions are involved in the process, and evidence is accumulating that defects in any one of these reactions may severely affect the optimal metabolic cascade. Proper exposure of receptor-binding domains in apoE and perhaps apoB-100 molecules is mandatory. Lipoprotein lipase-induced triglyceride hydrolysis is essential and responsible for the formation of remnant particles from secreted triglyceride-rich lipoproteins. The existence of apoE molecules that exhibit normal function is important but perhaps not always essential. Sequestration in the liver through lipoprotein lipase and/or apoE-mediated binding to heparan sulphate ('bridging' effect) appears to play an exceedingly important role during the early phase of the remnant clearance process. The 'bridging' is responsible not only for sequestration in the liver but also for enhanced uptake and lysosomal degradation of the particles. At this stage, association with the remnants of newly secreted, liver-derived apoE molecule...Continue Reading

References

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Citations

Apr 21, 1999·Progress in Lipid Research·D A Chappell, J D Medh
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·N MeroM R Taskinen

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