Remodeling of articular defects in an animal model

Clinical Orthopaedics and Related Research
Thomas Trumble, James Verheyden

Abstract

When treating displaced intraarticular fractures, the goal has been to restore normal articular cartilage contour to decrease local contact stresses that may lead to the development of posttraumatic osteoarthritis. To confirm observations that articular cartilage step-offs can remodel with time and to determine how the articular surface and subchondral bone remodels after an intraarticular fracture, joint surface changes were examined in a weightbearing sheep model with an intraarticular fracture. Articular surface pressure changes were observed across a 1-mm osteotomy. Twelve weeks after an intraarticular osteotomy, there was a decrease in differential pressure distribution between the normal articular cartilage and the depressed articular surface. Histologic analysis showed thinning of the articular cartilage on the high side of the osteotomy with collagen compression and bending of the collagen fibrils. On the low side of the osteotomy, increased chondrocyte cellularity and hypertrophy were observed. In addition, bending of collagen fibrils was observed in an unloaded state in an attempt to form a smooth overlapping shelf at the osteotomy site. Because intraarticular incongruency, with resultant joint contact pressure differ...Continue Reading

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Citations

Apr 27, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Donald D AndersonJoseph A Buckwalter
Feb 11, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chen Hua YeowJames Cho Hong Goh
Jun 20, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ching-Chuan JiangRocky S Tuan
Aug 30, 2008·International Orthopaedics·Christian Allende, Bartolomé T Allende
Mar 2, 2010·Tissue Engineering. Part C, Methods·Hongsen ChiangChing-Chuan Jiang
Sep 28, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Qian ZhangJiong Jiong Guo

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