Remodeling of intramural thrombus and collagen in an Ang-II infusion ApoE-/- model of dissecting aortic aneurysms.

Thrombosis Research
Andreas J SchrieflJay D Humphrey

Abstract

Fibrillar collagen endows the normal aortic wall with significant stiffness and strength and similarly plays important roles in many disease processes. For example, because of the marked loss of elastic fibers and functional smooth cells in aortic aneurysms, collagen plays a particularly important role in controlling the dilatation of these lesions and governing their rupture potential. Recent findings suggest further that collagen remodeling may also be fundamental to the intramural healing of arterial or aneurysmal dissections. To explore this possibility further, we identified and correlated regions of intramural thrombus and newly synthesized fibrillar collagen in a well-established mouse model of dissecting aortic aneurysms. Our findings suggest that intramural thrombus that is isolated from free-flowing blood creates a permissive environment for the synthesis of fibrillar collagen that, albeit initially less dense and organized, could protect that region of the dissected wall from subsequent expansion of the dissection or rupture. Moreover, alpha-smooth muscle actin positive cells appeared to be responsible for the newly produced collagen, which co-localized with significant production of glycosaminoglycans.

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Citations

Mar 16, 2013·Biomechanics and Modeling in Mechanobiology·Sara RoccabiancaJay D Humphrey
Feb 1, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Lilach GavishS David Gertz
Jul 12, 2014·BioMed Research International·Andre Bento Chaves SantanaSilvia Lacchini
Mar 1, 2013·Journal of Biomechanical Engineering·J S WilsonJ D Humphrey
Nov 3, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Manuel K Rausch, Jay D Humphrey
Dec 28, 2012·Journal of the Royal Society, Interface·Andreas J SchrieflGerhard A Holzapfel
Jun 11, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Sara MartorellLaura Piqueras
Feb 8, 2018·Scientific Reports·Alireza YazdaniGeorge Em Karniadakis
Apr 29, 2020·PLoS Computational Biology·Xiaoning ZhengGeorge E Karniadakis
Jan 23, 2015·Journal of Biomechanical Engineering·Shahrokh Zeinali-DavaraniYanhang Zhang
Nov 23, 2017·Journal of Vascular Research·Evan H PhillipsCraig J Goergen

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