PMID: 11329130May 1, 2001Paper

Remodeling of motor terminals during metamorphosis of the moth Manduca sexta: expression patterns of two distinct isoforms of Manduca fasciclin II

The Journal of Comparative Neurology
Laura M KnittelKarla S Kent

Abstract

During metamorphosis of the moth Manduca sexta, the neuromuscular system of the thoracic legs is reorganized dramatically. Larval leg muscles degenerate at the end of larval life, and new adult leg muscles develop during the ensuing pupal stage. Larval leg motoneurons persist, but undergo substantial remodeling of central and peripheral processes. As part of our on-going investigation of mechanisms underlying the remodeling of motor terminals, we have used antisera generated against Manduca-specific isoforms of the homophilic adhesion molecule fasciclin II (MFas II) to label motor terminals during metamorphosis. Antisera generated against the glycosyl-phosphatidylinositol (GPI) -linked isoform of MFas II (GPI-MFas II) labeled the motor nerves at all stages and seemed to be associated with glial cells ensheathing the peripheral nerves. In addition, the anti-GPI-MFas II antisera labeled regions associated with synaptic boutons at both larval and adult stages. In contrast, antisera generated against a transmembrane isoform of MFas II (TM-MFas II) only labeled specific neuronal processes at discrete intervals during remodeling. Identified leg motoneurons (such as the femoral depressor motoneuron) expressed detectable levels of TM-M...Continue Reading

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Citations

May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erin S BeckBrian D McCabe
Aug 2, 2005·Developmental Biology·Sarita Hebbar, Joyce J Fernandes
Dec 23, 2003·The Journal of Comparative Neurology·Patricia K RivlinDavid L Deitcher
Aug 13, 2004·Journal of Neurobiology·Sarita Hebbar, Joyce J Fernandes
Jul 14, 2006·Journal of Neurobiology·Sarita HebbarJoyce J Fernandes

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